Although there are several possible explanations for the occurrence of anemia in children with meningitis, Kaplan and Oski1 have neglected iatrogenic blood loss as a contributory cause. For the sake of discussion, assume that a child loses 60 ml of blood in four days, given the list of tests that the authors cite and the fact that the children with Haemophilus tend to be more ill than the other patients. If a 10-kg child has a blood volume of 750 ml, then the Table shows that by day 4 (the hypothetical low point) the red cell volume (hematocrit times blood volume) would have declined by 24 ml.

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