Measles immunity was studied in children in a private pediatric practice who had been revaccinated because they had received their primary measles vaccination before 1 year of age. Antibody was measured in 72 of these children who had received the first injection of live measles virus vaccine at <10 months of age, and the second at >1 year of age. Of the 72 children, 29 (40%) had no detectable antibody and the geometric mean titer for the group was approximately 1:4. Of the children with low antibody titers, 15 were given a third injection of measles vaccine and five (33%) still did not respond. Cell- mediated immunity as indicated by lymphocyte transformation to measles antigen was measured in 11 of the children. Five (45%) had responses to measles antigen, but the responses did not correlate with the presence or absence of antibody. This study confirms the observation that revaccination is unsuccessful in many children who received measles vaccine in the first year of life, and shows that even a third injection of vaccine may fail to produce a significant antibody response.
Skip Nav Destination
Article navigation
March 1982
Articles|
March 01 1982
Measles Immunity After Revaccination: Results in Children Vaccinated Before 10 Months of Age
Calvin C. Linnemann, Jr;
Calvin C. Linnemann, Jr
Departments of Medicine (Infectious Disease Division), Pediatrics, and Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, and Veterans Administration Medical Center, Cincinnati
Search for other works by this author on:
Mark S. Dine;
Mark S. Dine
Departments of Medicine (Infectious Disease Division), Pediatrics, and Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, and Veterans Administration Medical Center, Cincinnati
Search for other works by this author on:
Gary A. Roselle;
Gary A. Roselle
Departments of Medicine (Infectious Disease Division), Pediatrics, and Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, and Veterans Administration Medical Center, Cincinnati
Search for other works by this author on:
P. Anne Askey
P. Anne Askey
Departments of Medicine (Infectious Disease Division), Pediatrics, and Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, and Veterans Administration Medical Center, Cincinnati
Search for other works by this author on:
Pediatrics (1982) 69 (3): 332–335.
Article history
Received:
February 17 1981
Accepted:
May 06 1981
Citation
Calvin C. Linnemann, Mark S. Dine, Gary A. Roselle, P. Anne Askey; Measles Immunity After Revaccination: Results in Children Vaccinated Before 10 Months of Age. Pediatrics March 1982; 69 (3): 332–335. 10.1542/peds.69.3.332
Download citation file:
0 Comments
Comments Icon
Comments (0)
Sign in
Don't already have an account? Register
Pay-Per-View Access
$25.00
0
Views
0
Citations