The recent article by Hecht et al1 provided a comprehensive summary of this area of genetics that is of particular importance to pediatricians. I would like to add two recent findings of interest.

First, Webb et a12 have reported a family with a male of normal intelligence and the fragile X marker chromosome. He was ascertained through his daughter who had a mentally retarded son with the associated fragile site and in addition the daughter showed the fragile X confirming her obligate carrier status.

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