Large numbers Clostridium difficile were found in the stools of two victims of sudden infant death syndrome (SIDS). This prompted a study of normal infants in the SIDS age group. Thirty-two infants were studied, using two selective culture techniques and two assays for bacterial products. Thirteen of the normal infants (39%) were found to carry C difficile, and fecal toxins were detected in eight of these, four with cytotoxin detectable at 10-4 or higher dilution. Colonization was observed in one of 13 (7%) breast-fed babies and 12 of 17 (71%) of those whose primary milk source was infant formula (P < .01). Fecal C difficile toxin was detected only in the latter group. The isolation of C difficile or its toxins in the stools of infants with SIDS, diarrhea, or other conditions must thus be interpreted with caution, even if large quantities of fecal cytotoxin are present.
Clostridium difficile in Normal Infants and Sudden Infant Death Syndrome: An Association with Infant Formula Feeding
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Michael S. Cooperstock, Earl Steffen, Robert Yolken, Andrew Onderdonk; Clostridium difficile in Normal Infants and Sudden Infant Death Syndrome: An Association with Infant Formula Feeding. Pediatrics July 1982; 70 (1): 91–95. 10.1542/peds.70.1.91
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