Desquamative interstitial pneumonia was observed in two infants with the late-onset congenital rubella syndrome. In both infants this unusual lung disease was associated with circulating immunoglobulin M complexes and interstitial pulmonary deposits of IgM by immunofluorescence. Both infants had IgG deficiency. The first child recovered with a reduction in IgM complex levels and synthesis of rubella-specific IgG. The second infant died during the acute phase of his illness at which time there were high serum concentrations of IgM complexes and slightly increased levels of IgG complexes. Delayed maturation of the immune response in congenital rubella may predispose to persistent antigenemia and pulmonary deposition of rubella antigen-containing IgM complexes resulting in an acute form of interstitial pneumonia.
Skip Nav Destination
Article navigation
December 1983
Articles|
December 01 1983
Desquamative Interstitial Pneumonia and Antigen-Antibody Complexes in Two Infants with Congenital Rubella
Attilio Boner;
Attilio Boner
From the Hospitals for Sick Children and St Mary's Hospital Medical School, London
Search for other works by this author on:
Robert W. Wilmott;
Robert W. Wilmott
From the Hospitals for Sick Children and St Mary's Hospital Medical School, London
Search for other works by this author on:
Robert Dinwiddie;
Robert Dinwiddie
From the Hospitals for Sick Children and St Mary's Hospital Medical School, London
Search for other works by this author on:
Donald J. Jeffries;
Donald J. Jeffries
From the Hospitals for Sick Children and St Mary's Hospital Medical School, London
Search for other works by this author on:
Duncan J. Matthew;
Duncan J. Matthew
From the Hospitals for Sick Children and St Mary's Hospital Medical School, London
Search for other works by this author on:
William C. Marshall;
William C. Marshall
From the Hospitals for Sick Children and St Mary's Hospital Medical School, London
Search for other works by this author on:
James F. Mowbray;
James F. Mowbray
From the Hospitals for Sick Children and St Mary's Hospital Medical School, London
Search for other works by this author on:
John R. Pincott;
John R. Pincott
From the Hospitals for Sick Children and St Mary's Hospital Medical School, London
Search for other works by this author on:
Rodney P. Rivers
Rodney P. Rivers
From the Hospitals for Sick Children and St Mary's Hospital Medical School, London
Search for other works by this author on:
Pediatrics (1983) 72 (6): 835–839.
Article history
Received:
April 03 1982
Accepted:
March 25 1983
Citation
Attilio Boner, Robert W. Wilmott, Robert Dinwiddie, Donald J. Jeffries, Duncan J. Matthew, William C. Marshall, James F. Mowbray, John R. Pincott, Rodney P. Rivers; Desquamative Interstitial Pneumonia and Antigen-Antibody Complexes in Two Infants with Congenital Rubella. Pediatrics December 1983; 72 (6): 835–839. 10.1542/peds.72.6.835
Download citation file:
0 Comments
Comments Icon
Comments (0)
Sign in
Don't already have an account? Register
Pay-Per-View Access
$25.00
1
Views
0
Citations