In Reply.—

We appreciate the comments of Welliver regarding our recent article. His primary concerns relate to the issue of causality, particularly the methodology of establishing a causal relationship.

These concerns are addressed in our article (Pediatrics 1984;74:1-10) as follows:

Although a historical cohort study cannot, by its nature, prove causality, this study's findings are consistent with the hypothesis that bronchiolitis is a causal factor in wheezing. One may speculate that there is a latent factor accounting for the observed bronchiolitis-wheezing association (possibly a genetic factor common both to children who develop bronchiolitis and to children who wheeze during middle childhood years) that is measured by none of the methods employed in this study.

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