In Reply.—

We are delighted that Dr Anbar has had the opportunity to independently test the validity and effectiveness of our algorithm on assisted ventilation against simulation programs. It is reassuring that, as in our group of infants, the simulated arterial blood gas derangements responded well to the ventilatory management recommended by our "expert system." The excellent rate of correction of blood gas values in both studies (89% and 90%) suggests that this area of medical care suits itself to the application of algorithms.

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