It has been shown that cortisone, injected into pregnant female mice, will produce cleft palate and other congenital malformations in the resulting young. The incidence of cleft palate varies according to the genetic constitution of the treated mice, the dosage of cortisone used and the gestational stage at which treatment is begun.

Topics:
congenital abnormality, cortisone, mice, offspring, pregnancy
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Copyright © 1951 by the American Academy of Pediatrics
1951
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