A 6-year-old girl had a 7-month history of headaches and painful torticollis. A CT scan of the mastoids showed extensive bone destruction of the base of the skull and C-1. Biopsies of the retropharyngeal area and of the anterior aspect of C-1 were performed: histopathologic findings were suggestive of mycotic infection and cultures were positive for Candida albicans. The child was treated successfully with amphotericin B. The immunologic evaluation demonstrated the absence o myeloperoxidase in the neutrophils.
Myeloperoxidase Deficiency With Extensive Candidal Osteomyelitis of the Base of the Skull
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Michel L. Weber, Anthony Abela, Louis de Repentigny, Laurent Garel, Normand Lapointe; Myeloperoxidase Deficiency With Extensive Candidal Osteomyelitis of the Base of the Skull. Pediatrics December 1987; 80 (6): 876–879. 10.1542/peds.80.6.876
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