The appearance of unexplained acute renal failure during the course of idiopathic nephrotic syndrome is an uncommon but well-reported phenomenon in adults.1 Its occurrence in childhood has not been reported. We present an 8-year-old girl with minimal change nephrotic syndrome in whom inexplicable acute renal failure developed following exploratory laparotomy.


This 8-year-old girl had a 6-year history of frequently relapsing, steroid-responsive nephrotic syndrome clinically consistent with minimal change disease. While visiting the Buffalo area with her family, she suddenly had severe constant abdominal pain associated with nausea and emesis and was brought to the emergency room for evaluation. She was receiving alternate-day prednisone in an attempt to reduce the number of her relapses.

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