To define the hematologic changes during a mild viral infection, 93 infants were immunized with live attenuated measles virus and studied prospectively at 0, 4, 9, 14, 21, and 30 days. Hemoglobin concentration decreased significantly by days 9 and 14. The decrease was >1.0 g/dL in 8.6% and >0.6 in 24.3% of the infants. of the nonanemic infants, 22% became anemic. Serum iron and percentage saturation of transferrin decreased, whereas serum ferritin increased significantly. Mean cell volume, iron-binding capacity, protoporphyrin, and haptoglobin did not show changes. Reticulocyte index and erythropoietin increased significantly at 30 days. Leukocyte counts, Zetacrit, and C-reactive protein did not help to predict the hemoglobin decrease. These results suggest that a mild viral infection in infants induces a significant decrease in hemoglobin that may persist for 14 to 30 days and may be difficult to distinguish from iron deficiency.
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November 1989
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November 01 1989
Anemia of a Mild Viral Infection: The Measles Vaccine as a Model
Manuel Olivares;
Manuel Olivares
The Hematology and Immunology Units, Instituto de Nutrición and Tecnologia de los Alimentos, Universidad de Chile, Santiago
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Tomas Walter;
Tomas Walter
The Hematology and Immunology Units, Instituto de Nutrición and Tecnologia de los Alimentos, Universidad de Chile, Santiago
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Marcial Osorio;
Marcial Osorio
The Hematology and Immunology Units, Instituto de Nutrición and Tecnologia de los Alimentos, Universidad de Chile, Santiago
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Patricia Chadud;
Patricia Chadud
The Hematology and Immunology Units, Instituto de Nutrición and Tecnologia de los Alimentos, Universidad de Chile, Santiago
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Liana Schlesinger
Liana Schlesinger
The Hematology and Immunology Units, Instituto de Nutrición and Tecnologia de los Alimentos, Universidad de Chile, Santiago
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Pediatrics (1989) 84 (5): 851–855.
Article history
Received:
August 30 1988
Accepted:
December 08 1988
Citation
Manuel Olivares, Tomas Walter, Marcial Osorio, Patricia Chadud, Liana Schlesinger; Anemia of a Mild Viral Infection: The Measles Vaccine as a Model. Pediatrics November 1989; 84 (5): 851–855. 10.1542/peds.84.5.851
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