An association between blue sclerae and iron deficiency anemia (IDA) was described in 1908 by W. Osler1 and confirmed recently in adults.2 In these studies, blue sclerae appeared more sensitive and equally specific as an indicator of IDA than mucosal pallor.4 Because IDA is common in young children even in industrialized countries, and since infants with IDA may be at risk for long-lasting developmental impairment,9-11 we carried out a survey to verify the validity of this association and to assess the value of this clinical sign in a pediatric population.


One hundred hospitalized children (median age 3.3 years, range 2 months to 17 years) were prospectively studied in accordance with the ethics committee of our institution.

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