We thank Dr Woods for his thoughtful comment emphasizing the importance of submitting a sufficient quantity of blood for culturing. Blood cultures are recommended for all infants and accurate results are required for further management. Dr Woods raises a good point about the volume required to assess IMs in blood, a particular concern in the youngest infants, 8 to 21 days. In this group, IMs are not needed for initial decision-making because the guideline recommends all 8- to 21-day-old infants have CSF evaluated, antimicrobial agents administered, and close observation in hospitals with staff experienced in the care of young infants. Accordingly, the key action statement intentionally does not state that IMs “should” be obtained in this age group. Some members of the subcommittee find IMs potentially useful later in the course of hospitalization for addressing what may be falsepositive culture results or determining length of stay, so the key action...

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