Sickle cell disease (SCD), a group of inherited disorders, is a bellwether example of a chronic, disabling, life-threatening condition that is disproportionately underserved by the medical community. SCD is arguably associated with the most significant health inequities of both the 20th and 21st centuries. Although these inequities, which are linked to historical interpersonal and institutional racism, have been long recognized, there has been scant progress in closing the health care gaps.1 SCD affects at least 100c000 individuals in the United States, the vast majority being Black or African American individuals.1 Abnormal hemoglobin produced in SCD causes red blood cells (RBCs) to sickle, clogging blood flow and leading to vasoocclusive crises and potential impacts on every organ system. Persons with SCD experience numerous complications, including recurrent episodes of severe pain, pneumonia and acute chest syndrome, stroke, and organ damage. Estimated life expectancy of those with SCD in...
Prioritizing Sickle Cell Disease
FUNDING: No external funding.
CONFLICT OF INTEREST DISCLAIMER: Dr Hsu reports institutional support from the Health Resources and Services Administration, the National Institutes of Health, the European Commission, the Illinois Department of Public Health, the Joy in Childhood Foundation, Global Blood Therapeutics, Forma Therapeutics, Imara, Baxalta, Cyclerion, and Eli Lilly; consulting fees from DuPont Nemours Children’s Hospital, Hoffman-LaRoche, DisperSol, Guidepoint, Magellan, Deerfield, and Kuwait University; speaker honoraria from the Foundation for Sickle Cell Disease Research, Bridgeport Hospital, and Tova Health Center; participation on an Aruvant Data Safety Monitoring Board and service as a scientific advisor or member of an expert advisory board for the National Institutes of Health Sickle Cell Disease Advisory Committee, Hilton Publishing/HPC, and the Illinois Universal Newborn Screening Advisory Committee; and unpaid membership in the Sickle Cell Disease Association of America, the Sickle Cell Disease Association of Illinois, and the National Alliance of Sickle Cell Centers. All other authors have indicated they have no conflicts of interest relevant to this article to disclose.
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Lewis L. Hsu, W. Craig Hooper, Laura A. Schieve; Prioritizing Sickle Cell Disease. Pediatrics 2022; e2022059491. 10.1542/peds.2022-059491
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