Introduction Children with cancer experience significant physiologic and emotional stress. Although data are sparse and difficult to collect, creative modalities such as art therapy may help reduce stress-related signs and symptoms in pediatric oncology patients. This study examines whether patients undergoing chemotherapy regimens perceive art therapy to help them during treatment. Methods: Patients ages 6-21, actively receiving chemotherapy for newly diagnosed or relapsed cancers, were recruited from the inpatient and outpatient oncology service of an urban community hospital. All patients were offered art therapy during their treatment regimen. All patients, whether they participated in art therapy or not, were invited to complete a one-time peer-reviewed survey, ascertaining their perceptions regarding art therapy. Patients and parents completed assent and consent forms, respectively. Patients were placed into three groups; no art therapy, art therapy for 3-6 months, art therapy for 12-15 months. Preliminary data are presented here. Results: Nine of the 13 initial patients participated in art therapy at least once. All patients who participated in art therapy felt that art therapy helped them during cancer treatment. 100% of those who participated in art therapy, regardless of duration, agreed that art therapy could help other children with cancer, while only 50% of those who did not participate agreed. Additional questions ascertained if the participants ever felt sad during treatment, and if they thought art therapy would help if they felt sad during their oncological treatment. For those who did not participate in art therapy, 50% felt sad during their treatment and 25% felt art therapy could help with their sadness. Of those who had participated in art therapy, all felt sad during their treatment and approximately 75% felt art therapy could help with their sadness. Discussion: Though this study is ongoing, preliminary data suggest that art therapy may relieve subjectively-reported stress-related symptoms among pediatric oncology patients; all patients who received art therapy reported that it was helpful. Reported differences in perception between patients who received art therapy and those who didn't are difficult to interpret given the non-randomized study design, but may be explored further once additional patients are enrolled and data collected.