Background: Episodes of severe acute pain are a major feature of sickle cell disease (SCD), a genetic disorder predominantly affecting persons of African descent. Because minority groups in the United States are more likely to have reading levels below the national average of 8th - 9th grade, it is essential that online information about SCD meets the recommendation that health-related information should be written at 6th grade level or lower. We assessed the readability of online information on sickle cell pain in children. Methods: We conducted online searches for “child with sickle cell pain” and “preventing sickle cell pain” using Google search engine. Websites in English on the first two pages of our search were assessed for readability using Flesch Kincaid Reading Ease Score (FRES) and Flesch Kincaid Grade Level (FKGL) with an online tool. Results: 32 unique websites out of 40 entered the readability analysis (Table 1). Thirty (93.8%) were patient-targeted and 17 (53.1%) were published by a Children’s or University hospitals. The reading level by FKGL ranged from -0.7 to 11.1. Only 8 (25%) were at 6th grade or lower. The mean FRES was 66.5 (range 30.6– 102.3) indicating the material was written for 8th-9th grade level. Conclusion: The readability of highly ranked information in Google about SCD pain in children does not meet the recommended 6th grade level for health-related information intended for patients and their families. Adolescents with SCD and parents of children with SCD could benefit from easier to read online material.