We describe 2 children with persistent fever and profuse diarrhea who developed signs of mucocutaneous involvement (conjunctivitis, fissured lips, skin rash, erythema, and edema of the hands and feet). Blood tests revealed elevated markers of inflammation, lymphopenia, thrombocytopenia, and complement consumption. Afterward, diffuse edema with hypoalbuminemia appeared in the context of a capillary leak syndrome. In both patients, repeated nasal swabs were negative for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but each patient had high titers of immunoglobulin G and immunoglobulin M against the SARS-CoV-2 virus. The negative PCR results in the presence of immunoglobulin M and immunoglobulin G suggested that the inflammatory response developed in the late phase of viral infection, when SARS-CoV-2 was not detectable in the upper airway. In this report, we describe patients with what we propose to name as SARS-CoV-2–induced Kawasaki-like hyperinflammatory syndrome. SARS-CoV-2–induced Kawasaki-like hyperinflammatory syndrome seems to be caused by a delayed response to SARS-CoV-2. It resembles Kawasaki disease complicated by macrophage activation syndrome, although it has peculiar features, such as prodromal diarrhea, capillary leak syndrome, and myocardial dysfunction. Intravenous corticosteroid treatment appears to be helpful.
On January 7, 2020, the Chinese Center for Disease Control and Prevention isolated a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), from the throat swab sample of a patient affected by interstitial pneumonia. Since then, SARS-CoV-2 cases have spread rapidly throughout China and worldwide, leading the World Health Organization to declare a pandemic state on March 11, 2020. SARS-CoV-2 initial symptoms are flulike, such as rhinorrhea, fever, cough, fatigue, myalgia, and, less frequently, diarrhea. In some patients, the infection can lead to severe interstitial pneumonia, followed by multiorgan failure. Since the first reports, the development of systemic inflammation has been proposed as a key factor related to poor outcomes.1
Preliminary data suggest that SARS-CoV-2 infection in children is usually milder. In Italy, as of May 8, 2020, 215 665 people were infected with SARS-CoV-2, with <2% being <18 years of age. Only three pediatric deaths have been reported.2 Systemic hyperinflammation due to SARS-CoV-2 infection is currently considered rare in children.3 The initial case patient appears to have been a 6-month-old girl with SARS-CoV-2 who presented with conjunctivitis, polymorphous rash, swollen extremities, and persistent fever. This patient was treated as if she had Kawasaki disease (KD) with intravenous immunoglobulin and acetylsalicylic acid and improved.4
In this report we describe two cases of severe hyperinflammation with similar clinical and laboratory findings. Neither patient had a positive nasal swab result, but both had high immunoglobulin G (IgG) and immunoglobulin M (IgM) titers against SARS-CoV-2.
Case Reports
Patient 1
On April 14, 2020, a 12-year-old boy presented to our emergency department with a 2-day history of high fever and abdominal pain. His previous medical history was unremarkable. On admission, blood tests revealed significant lymphocytopenia (lymphocyte level of 560 cells per mm3) and elevated levels of inflammatory markers (Fig 1). A nasopharyngeal swab was negative for SARS-CoV-2. A chest radiograph and echocardiogram were normal, whereas an abdominal ultrasound revealed mesenteric lymphadenitis. Empirical antibiotics were started, without clinical improvement. During the following days, he developed mild conjunctivitis, erythema and cracked lips, skin rash, erythema and edema of the hands and feet, petechial elements (Fig 2), persistent high fever, diarrhea (10–20 times daily), and vomiting. He also developed mild thrombocytopenia, complement consumption, pleural effusion, weight gain, hypoalbuminemia with mild proteinuria, and an increased ferritin level (580 ng/mL). Treatment with methylprednisolone at 2 mg/kg was initiated, with immediate defervescence, prompt general improvement, and normalization of blood tests. Meanwhile, he developed cardiac involvement (reduced systolic function and pericardial effusion on an echocardiogram, elevated troponin T levels with normal creatine kinase myocardial band levels, and electrocardiographic signs of myocardial injury). He continued intravenous corticosteroid for 2 weeks, with subsequent normalization of cardiac function.
Time line of patients’ symptoms, laboratory findings, and therapy. Laboratory findings are expressed as a ratio of the normal value. Normal values were considered as follows: CRP, 10 mg/L; fibrinogen, 300 mg/dL; procalcitonin, 2 ng/mL; lymphocytes, 1500 cells per mm3; platelet count, 250 000/mm3; and ferritin, 150 ng/mL. IV, intravenous; IVIg, intravenous immunoglobulin.
Time line of patients’ symptoms, laboratory findings, and therapy. Laboratory findings are expressed as a ratio of the normal value. Normal values were considered as follows: CRP, 10 mg/L; fibrinogen, 300 mg/dL; procalcitonin, 2 ng/mL; lymphocytes, 1500 cells per mm3; platelet count, 250 000/mm3; and ferritin, 150 ng/mL. IV, intravenous; IVIg, intravenous immunoglobulin.
Cutaneous manifestations on day 5 of illness. Patient 1: A, erythema and cracking of lips; B, mild conjunctivitis; C, erythema and edema of the hands; D, petechial elements on feet. Patient 2: E, modest eyelid erythema; F, skin rash on palms; G, cutaneous erythema; H, petechial elements on feet.
Cutaneous manifestations on day 5 of illness. Patient 1: A, erythema and cracking of lips; B, mild conjunctivitis; C, erythema and edema of the hands; D, petechial elements on feet. Patient 2: E, modest eyelid erythema; F, skin rash on palms; G, cutaneous erythema; H, petechial elements on feet.
Patient 2
On April 18, 2020, a 7-year-old boy arrived in our emergency department with a 5-day history of fever, nausea and vomiting, diarrhea, and abdominal pain. He had a previous diagnosis of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis. Both parents were health care workers. The mother had anosmia and taste dysfunction for 1 month. A physical examination revealed bilateral conjunctivitis; modest eyelid and scrotal erythema; skin rash on palms and soles, limbs, and back; petechial elements in the lower limbs; dry lips; and de-epithelialized tongue (Fig 2). Blood tests revealed lymphocytopenia, thrombocytopenia, low C3 and C4 levels, hypoalbuminemia, and significantly increased levels of ferritin (897 ng/mL) and other inflammatory markers (Fig 1). A chest radiograph and electrocardiogram were normal, whereas an ultrasound of the abdomen revealed the presence of enlarged mesenteric lymph nodes. A nasopharyngeal swab specimen was negative for SARS-CoV-2. Broad-spectrum empirical antibiotics were started. Subsequently, the patient developed hypotension, tachycardia, and tachypnea with oxygen desaturation. Noninvasive respiratory support was initiated, and he received a crystalloid solution, followed by vasopressors. After fluid resuscitation he developed right pleural effusion and cardiomegaly. Laboratory and instrumental tests on hospital day 3 (illness day 7) confirmed the cardiac injury (eg, abnormal troponin T levels, elevated pro-brain natriuretic peptide levels, and high levels of D-dimer, with reduced systolic function on echocardiography). Treatment was switched to intravenous immunoglobulin at 2 g/kg and methylprednisolone at 2 mg/kg, and we continued antibiotic therapy. The patient had progressive improvement in clinical condition, laboratory, and imaging results.
Because of the uncertainty about the cause of both of these cases, we measured anti–S-specific IgG antibodies to SARS-CoV-2 (LIAISON SARS-CoV-2 S1/S2 IgG [reported specificity 98.5%]; DiaSorin, Saluggia, Italy) and found that both patients had moderate to high positive titers of IgG antibodies versus SARS-CoV-2. A second confirmatory test (Eradikit COVID19 [reported specificity 98.1%]; In3Diagnostic, Turin, Italy) found IgG and IgM antibodies directed toward SARS-CoV-2 in both patients.
Discussion
These two cases reveal a novel severe inflammatory syndrome that may develop in children during the late phase of SARS-CoV-2 infection. SARS-CoV-2 acute infection may mimic KD because it may present with persistent fever, rash, and conjunctivitis; our cases highlight that SARS-CoV-2 infection may trigger a severe inflammatory syndrome even after seroconversion, when the virus might not be detected in upper airways.5
These two patients presented with diarrhea, abdominal pain, high fever, elevated C-reactive protein (CRP) and procalcitonin levels, and a low lymphocyte count (phase1). Despite appropriate broad-spectrum antibiotic therapy, fever persisted, and mucocutaneous involvement appeared: conjunctivitis, fissured lips, and acral rash. Both then developed, in phase 2 of their illness, progressive thrombocytopenia, C3 and C4 consumption, hepatomegaly, capillary leak syndrome with severely decreased albuminemia, diffuse edema, and, in one case, severe hypotension requiring fluid resuscitation therapy. Both patients improved after intravenous corticosteroid therapy, but they developed what appeared to be myocarditis in a third phase.
On initial presentation, we believed they had a gastrointestinal bacterial infection. In the second phase, both patients fulfilled KD diagnostic criteria. However, they had unusual features, such as the age at disease onset and a low platelet count. This last finding is not frequent among patients with KD, except when macrophage activation syndrome (MAS) simultaneously develops. MAS is a rare life-threatening complication of autoinflammatory and autoimmune diseases6 that develops in 1.1% to 1.9% of patients with KD. In 2015 Wang et al7 published a report of 8 patients with macrophage activation syndrome in Kawasaki disease (MAS-KD). All patients had serum ferritin levels >684 ng/mL and aspartate aminotransferase levels >100 U/L, 87.5% had a platelet count of <100 000/mm3. Coronary involvement occurred in 25% of patients.
MAS-KD has many similarities with the clinical picture of our patients, although these two patients had unique features (Supplemental Table 1), such as the absence of coronary involvement, the development of myocardial dysfunction, and rapidly progressive capillary leak syndrome.
Our patients did not have a PCR positive for SARS-CoV-2, but they had serological evidence of an infection by using two different and highly specific tests. Although little is known regarding the antibody kinetics, presence of IgM versus SARS-CoV-2 may be considered as a marker of a recent infection.8 IgM cross-reactivity is improbable because nasal swabs were negative for other coronaviruses (229E, NL63, OC43, and HKU1).
The association between coronaviruses and KD was hypothesized in the past; in particular, Esper et al9 in 2005 found a PCR positive for New Haven coronavirus in 8 of 11 infants with classic KD. Regarding SARS-CoV-2, recent reports suggest that it causes capillary inflammation in the lungs and skin, with complement activation through both alternative and lectin pathways.10 A direct viral infection of the endothelial cells and diffuse endothelial inflammation can be found in the kidneys, heart, and liver of patients affected by SARS-CoV-211 . SARS-CoV-2 shares this capillary tropism with other coronaviruses; in particular, severe acute respiratory syndrome coronavirus 1 causes complement activation in mouse lungs, and C3−/− mice have considerably less respiratory dysfunction than wild-type mice.12 These data suggest that the mucocutaneous involvement, as well as the decrease of C3, C4, and platelet counts, may be a consequence of a microvasculopathy that leads to capillary leakage. The clinical picture described in our report has many analogies with a well-known hyper inflammatory syndrome caused in cats by feline coronavirus: feline infectious peritonitis. Feline infectious peritonitis is a fatal immune-mediated disease; its effusive form is characterized by fluid accumulation in body cavities as a consequence of immune complex deposition and macrophage activation.13
Tavazzi et al14 demonstrated the presence of viral SARS-CoV-2 particles in a myocardial biopsy of a patient with severe myocarditis. SARS-CoV-2 infection can be a trigger for cardiac injury, secondary to a combination of direct vascular and myocardial infection plus proinflammatory stimulation, which can occur at the same time or even post infection.15
We emphasize that heart function improved slowly; further follow-up will be needed to determine if heart function will fully recover.
These two patients had mild respiratory symptoms. In fact, the most significant manifestation was diarrhea. We are now evaluating whether SARS-CoV-2 is present in the stools, but the validity of such testing is unknown.
Conclusions
SARS-CoV-2 infection appears to have led to a late-phase serious inflammatory syndrome in these two children. Although the clinical presentation bears some similarities to KD-MAS, unusual features, such as capillary leak, were present. We propose that this clinical phenotype be named SCiKH syndrome (or SARS-CoV-2–induced Kawasaki-like hyperinflammatory syndrome).
Acknowledgments
We thank Prof Rossana Cavallo and Drs Maria Avolio and Barbara Colitti for performing serological tests; Drs Marisa Zoppo, Federica Mignone, Silvia Garazzino, and Carlo Scolfaro for clinical management of patients; Monica Mantovani for English language revision; Cecilia Pruccoli for providing graphic support; and all the ICU and emergency department doctors who helped us in treating these patients.
Dr Licciardi gave substantial contribution to conception and design, drafted the article, and reviewed and revised the manuscript; Drs Pruccoli and Denina contributed to conception and design, collected data, described the case reports, and reviewed and revised the manuscript; Drs Parodi and Taglietto collected data, provided iconography, and revised the manuscript; Prof Rosati performed the serological test and interpretation of data and reviewed the manuscript; Dr Montin supervised data collection and critically reviewed and revised the manuscript; and all authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work.
FUNDING: No external funding.
- CRP
C-reactive protein
- IgG
immunoglobulin G
- IgM
immunoglobulin M
- KD
Kawasaki disease
- MAS
macrophage activation syndrome
- MAS-KD
macrophage activation syndrome in Kawasaki disease
- PCR
polymerase chain reaction
- SARS-CoV-2
severe acute respiratory syndrome coronavirus 2
Comments
RE: SARS-CoV-2-Induced Kawasaki-Like Hyperinflammatory Syndrome: A Novel COVID Phenotype in Children
The SARS-CoV-2-Induced Kawasaki-Like Hyperinflammatory (SCiKH) syndrome shares with Kawasaki Disease (KD) fever and mucocutaneous features (conjunctivitis, cracking of lips, skin rash, erythema, and edema of the hands and feet). Although other features of SCiKH may be present also in KD, their frequency in that latter disease is quite low, whereas they are very common (almost distinctive features) in SCiKH: gastrointestinal involvement, extremely elevated serum procalcitonin, low lymphocyte count, low platelet count, complement consumption, high D-dimer, diffuse edema, and myocardial dysfunction. (1–4)
Overall, it seems we are facing a new disease (as rightly pointed out by Belhadjer and colleagues) (3) that, in our opinion, should be added in the differential diagnosis of KD together with other infectious diseases (eg measles, adenovirus, enterovirus, staphylococcal and streptococcal toxin-mediated diseases, leptospirosis). (5)
Cases published so far were mainly managed world-wide with intravenous immunoglobulins (IVIG) and, in some cases with corticosteroids (CS). (2,3) At the moment, however, strong evidence of efficacy cannot be deduced from published case series and it is difficult to define outcomes in a new disease. Even if the role of IVIG in KD is fundamental, some features of SCiKH suggest being cautious with Ig infusion in this new disease. In fact, IVIG administration provides an extra fluid amount of 40 ml per kilogram, which could cause volume overload and could worsen the cardiac function in patients with myocardial dysfunction. Moreover, SCiKH patients have complement consumption that could be ascribed to activation of the lectin pathway secondary to immune-complexes formation; in this context, the administration of immunoglobulins could be inappropriate. Conversely, early CS therapy seems to be the real “game-changer” in treating SCiKH. So far we have treated with early intravenous CS without IVIG 3 patients, they all had an extremely good clinical outcome, while the only patient who was admitted to ICU was the one who received IVIG. Obviously, we are currently trying to investigate our hypothesis on a larger SCiKH cohort, also in relation to coronary aneurysm formation.
Regarding cardiac echography, none of our SCiKH patients have so far any dilatation or thrombi in the proximal coronary tract; therefore, cardiac dysfunction is unlikely to be due to coronary insufficiency. Moreover, MRI performed in 3 of our 4 patients did not disclose signs of myocardial edema and fibrosis.
Finally, none of our patients had meningeal signs; patient 1 complained of a moderate headache for two days, which disappeared after steroid start.
References
1. Licciardi F, Pruccoli G, Denina M, et al. SARS-CoV-2-Induced Kawasaki-Like Hyperinflammatory Syndrome: A Novel COVID Phenotype in Children. Pediatrics. May 2020. doi:10.1542/peds.2020-1711
2. Verdoni L, Mazza A, Gervasoni A, et al. An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study. Lancet. May 2020. doi:10.1016/S0140-6736(20)31103-X
3. Belhadjer Z, Méot M, Bajolle F, et al. Acute heart failure in multisystem inflammatory syndrome in children (MIS-C) in the context of global SARS-CoV-2 pandemic. Circulation. May 2020. doi:10.1161/CIRCULATIONAHA.120.048360
4. Viner RM, Whittaker E. Kawasaki-like disease: emerging complication during the COVID-19 pandemic. Lancet. May 2020. doi:10.1016/S0140-6736(20)31129-6
5. McCrindle BW, Rowley AH, Newburger JW, et al. Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association. Circulation. 2017;135(17):e927-e999.
RE: SARS-CoV-2-Induced Kawasaki-Like Hyperinflammatory Syndrome: A Novel COVID Phenotype in Children
The SARS-CoV-2-Induced Kawasaki-Like Hyperinflammatory (SCiKH) syndrome shares with Kawasaki Disease (KD) fever and mucocutaneous features (conjunctivitis, cracking of lips, skin rash, erythema, and edema of the hands and feet). Although other features of SCiKH may be present also in KD, their frequency in that latter disease is quite low, whereas they are very common (almost distinctive features) in SCiKH: gastrointestinal involvement, extremely elevated serum procalcitonin, low lymphocyte count, low platelet count, complement consumption, high D-dimer, diffuse edema, and myocardial dysfunction 1–4.
Overall, it seems we are facing a new disease (as rightly pointed out by Belhadjer and colleagues) 3 that, in our opinion, should be added in the differential diagnosis of KD together with other infectious diseases (eg measles, adenovirus, enterovirus, staphylococcal and streptococcal toxin-mediated diseases, leptospirosis) 5.
Cases published so far were mainly managed world-wide with intravenous immunoglobulins (IVIG) and, in some cases with corticosteroids (CS) 2,3. At the moment, however, strong evidence of efficacy cannot be deduced from published case series and it is difficult to define outcomes in a new disease. Even if the role of IVIG in KD is fundamental, some features of SCiKH suggest being cautious with Ig infusion in this new disease. In fact, IVIG administration provides an extra fluid amount of 40 ml per kilogram, which could cause volume overload and could worsen the cardiac function in patients with myocardial dysfunction. Moreover, SCiKH patients have complement consumption that could be ascribed to activation of the lectin pathway secondary to immune-complexes formation; in this context, the administration of immunoglobulins could be inappropriate. Conversely, early CS therapy seems to be the real “game-changer” in treating SCiKH. So far we have treated with early intravenous CS without IVIG 3 patients, they all had an extremely good clinical outcome, while the only patient who was admitted to ICU was the one who received IVIG. Obviously, we are currently trying to investigate our hypothesis on a larger SCiKH cohort, also in relation to coronary aneurysm formation.
Regarding cardiac echography, none of our SCiKH patients have so far any dilatation or thrombi in the proximal coronary tract; therefore, cardiac dysfunction is unlikely to be due to coronary insufficiency. Moreover, MRI performed in 3 of our 4 patients did not disclose signs of myocardial edema and fibrosis.
Finally, none of our patients had meningeal signs; patient 1 complained of a moderate headache for two days, which disappeared after steroid start.
1. Licciardi F, Pruccoli G, Denina M, et al. SARS-CoV-2-Induced Kawasaki-Like Hyperinflammatory Syndrome: A Novel COVID Phenotype in Children. Pediatrics. May 2020. doi:10.1542/peds.2020-1711
2. Verdoni L, Mazza A, Gervasoni A, et al. An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study. Lancet. May 2020. doi:10.1016/S0140-6736(20)31103-X
3. Belhadjer Z, Méot M, Bajolle F, et al. Acute heart failure in multisystem inflammatory syndrome in children (MIS-C) in the context of global SARS-CoV-2 pandemic. Circulation. May 2020. doi:10.1161/CIRCULATIONAHA.120.048360
4. Viner RM, Whittaker E. Kawasaki-like disease: emerging complication during the COVID-19 pandemic. Lancet. May 2020. doi:10.1016/S0140-6736(20)31129-6
5. McCrindle BW, Rowley AH, Newburger JW, et al. Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association. Circulation. 2017;135(17):e927-e999.
RE: SARS-CoV-2-Induced Kawasaki-Like Hyperinflammatory Syndrome: A Novel COVID Phenotype in Children
We read with interest the article by Licciardi et al.(1) In particular, we are of great interest in Patient 1 reported in the article. As the patient fitted the criteria (conjunctivitis, changes of lips, skin rash, erythema, and changes to extremities) to be made a diagnosis of classical Kawasaki Disease KD), we are wondering no standard therapy of intravenous immunoglobulin (IVIG) given for this patient. As a recent article of 35 patients, diagnosed multisystem inflammatory syndrome in children, were all administered IVIG, with favorable response in 25 of them, even though none of them meet the criteria of KD diagnosis.(2)
Furthermore, we are also curious about the echocardiographic findings of Patient 1, as to whether any coronary arterial anomalies observed while prominent suppressed cardiac function possibly relevant to coronary arterial insufficiency. Lastly, we would like to know whether neurological complaints were observed in Patient 1, as earlier similar reports also indicated a high incidence of neurological manifestations such as meningeal signs or headaches.(3-5)
References
1. Licciardi F, Pruccoli G, Denina M, Parodi E, Taglietto M, Rosati S, et al. SARS-CoV-2-Induced Kawasaki-Like Hyperinflammatory Syndrome: A Novel COVID Phenotype in Children. Pediatrics. 2020 (online published).
2. Belhadjer Z, Meot M, Bajolle F, Khraiche D, Legendre A, Abakka S, et al. Acute heart failure in multisystem inflammatory syndrome in children (MIS-C) in the context of global SARS-CoV-2 pandemic. Circulation. 2020 (online published).
3. Riphagen S, Gomez X, Gonzalez-Martinez C, Wilkinson N, Theocharis P. Hyperinflammatory shock in children during COVID-19 pandemic. Lancet. 2020(online published).
4. Toubiana J, Poirault C, Corsia A, Bajolle F, Fourgeaud J, Angoulvant F, et al. Outbreak of Kawasaki disease in children during COVID-19 pandemic: a prospective observational study in Paris, France. medRxiv. 2020:2020.2005.2010.20097394.
5. Verdoni L, Mazza A, Gervasoni A, Martelli L, Ruggeri M, Ciuffreda M, et al. An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study. Lancet. 2020 (online published).
RE: Reader response: SARS-CoV-2-Induced Kawasaki-Like Hyperinflammatory Syndrome: A Novel COVID Phenotype in Children
Dear Editor,
We read with interest the article by Licciardi et. We are of particular interest in Patient 1 reported in the article. As the patient fitted the criteria (conjunctivitis, changes of lips, skin rash, erythema, and changes to extremities) to be made a diagnosis of classical Kawasaki Disease KD), we are wondering no standard therapy of intravenous immunoglobulin (IVIG) given for this patient. As another recent article titled "Acute heart failure in multisystem inflammatory syndrome in children (MIS-C) in the context of global SARS-CoV-2 pandemic" by Belhadjer et al. in Circulation (DOI:10.1161/CIRCULATIONAHA.120.048360), all 35 patients were administered IVIG, with favorable response in 25 of them, even though none of them meet the criteria of KD diagnosis.
Dear Editor,
We read with interest the article by Licciardi et. We are of particular interest in Patient 1 reported in the article. As the patient fitted the criteria (conjunctivitis, changes of lips, skin rash, erythema, and changes to extremities) to be made a diagnosis of classical Kawasaki Disease KD), we are wondering no standard therapy of intravenous immunoglobulin (IVIG) given for this patient. As a recent article of 35 patients were all administered IVIG, with favorable response in 25 of them, even though none of them meet the criteria of KD diagnosis.1
Furthermore, we are also curious about the echocardiographic findings of Patient 1, as to whether any coronary arterial anomalies observed while prominent suppressed cardiac function possibly relevant to coronary arterial insufficiency. Lastly, we would like to know whether neurological complaints were observed in Patient 1, as earlier similar reports also indicated a high incidence of neurological manifestations such as meningeal sings or headaches.2-4
References
1. Belhadjer Z, Meot M, Bajolle F, Khraiche D, Legendre A, Abakka S, et al. Acute heart failure in multisystem inflammatory syndrome in children (MIS-C) in the context of global SARS-CoV-2 pandemic. Circulation. 2020 (online published).
2. Riphagen S, Gomez X, Gonzalez-Martinez C, Wilkinson N, Theocharis P. Hyperinflammatory shock in children during COVID-19 pandemic. Lancet. 2020(online published).
3. Toubiana J, Poirault C, Corsia A, Bajolle F, Fourgeaud J, Angoulvant F, et al. Outbreak of Kawasaki disease in children during COVID-19 pandemic: a prospective observational study in Paris, France. medRxiv. 2020:2020.2005.2010.20097394.
4. Verdoni L, Mazza A, Gervasoni A, Martelli L, Ruggeri M, Ciuffreda M, et al. An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study. Lancet. 2020 (online published).