Introduction: Intestinal amoebiasis is caused by the protozoon Entamoeba histolytica. Amebic colitis can mimic inflammatory bowel disease (IBD). Here we present a case of a girl who was initially thought to have ileocolic Crohn’s disease, but was found to have amebic colitis. The purpose of this report is to raise awareness about the importance of proper screening for infectious causes of bloody diarrhea before labeling a patient with IBD. Case Description: A 9-year-old African American female presented with history of multiple episodes of bloody diarrhea and non-bilious, non-bloody vomiting for 3 days, associated with cramping and tenesmus, and a recent weight loss of 10 pounds within a week. She recalled eating crab legs and playing with reptiles prior to the start of her symptoms. She presented in severe dehydration and had diffuse abdominal tenderness, but no distension, guarding, rigidity, rebound tenderness, and normoactive bowel sounds on exam. On investigations, CBC showed mild microcytic hypochromic anemia, leukocytosis with left shift, elevated CRP, ESR, and calprotectin. Initial infectious work up including Hepatitis panel, stool culture, Giardia and Cryptosporidium antigen, and stool viral PCR panel were negative. Entamoeba histolytica antigen was pending. She underwent upper gastrointestinal endoscopy and colonoscopy to rule out IBD. Biopsies revealed gastritis and colitis with ulcerative changes scattered throughout the gastrointestinal tract concerning for Crohn’s disease. The plan was to start systemic steroids but Entamoeba histolytica antigen came back positive, hence the patient was started on Metronidazole and Paromomycin. The symptoms improved and patient continued to do well on follow-up outpatient visits with Pediatric Infectious Disease. Discussion: Intestinal amebiasis is more common in tropical and sub-tropical areas with poor hygiene and poor sanitary conditions. The mode of transmission is mainly fecal-oral contamination. Patients with acute amebic colitis may have a varied presentation ranging from typical symptoms of watery stools containing blood and mucus, abdominal pain, or tenesmus, to a more fulminant presentation, as seen with ulcerative colitis. Stool PCR is highly sensitive and is now considered the gold standard for the diagnosis of amebiasis. Patients with clinical disease generally require treatment with two drugs: an amebicidal agent to eradicate trophozoites such as Metronidazole and a luminal cysticidal agent like Paromomycin. Conclusion: Amebic colitis is often mistakenly diagnosed as ulcerative colitis or Crohn’s disease due to many overlapping features on physical examination, laboratory studies, and colonoscopy findings. Hence, antigen test or stool PCR for enteropathogens should be completed in the evaluation of such cases. Great care must be taken to avoid mislabeling a patient suffering from amebic colitis with IBD and starting corticosteroids, as can lead to serious complications including fulminant colitis, perforation, and peritonitis.