Carbohydrate restriction is increasingly popular as a weight loss strategy and for achieving better glycemic control in people with diabetes, including type 1 and type 2 diabetes. However, evidence to support low-carbohydrate diets in youth (children and adolescents 2–18 years of age) with obesity or diabetes is limited. There are no guidelines for restricting dietary carbohydrate consumption to reduce risk for diabetes or improve diabetes outcomes in youth. Thus, there is a need to provide practical recommendations for pediatricians regarding the use of low-carbohydrate diets in patients who elect to follow these diets, including those with type 1 diabetes and for patients with obesity, prediabetes, and type 2 diabetes.
This clinical report will:
Provide background on current dietary patterns in youth, describe how moderate-, low-, and very low-carbohydrate diets differ, and review safety concerns associated with the use of these dietary patterns
Review the physiologic rationale for carbohydrate reduction in youth with type 1 diabetes and for youth with obesity, prediabetes, and type 2 diabetes
Review the evidence for low-carbohydrate diets in the management of youth with type 1 diabetes
Review the evidence for low-carbohydrate diets in the management of youth with obesity, prediabetes, and type 2 diabetes
Provide practical information for pediatricians counseling families and youth on carbohydrate recommendations for type 1 diabetes and for obesity, prediabetes, and type 2 diabetes
Introduction
Obesity is a serious diet-related problem in the US pediatric population. Conditions associated with obesity and insulin resistance, including prediabetes and type 2 diabetes, are increasing in children and adolescents.1 Although not caused by obesity, type 1 diabetes is also a common chronic disease in the pediatric population (children and adolescents 2–18 years of age), and the incidence is increasing.2 Nutrition recommendations are central to the treatment of diabetes, whether the cause is absolute insulin deficiency (type 1 diabetes) or insulin resistance and relative insulin deficiency (type 2 diabetes).3 Low-carbohydrate diets have been used for decades and are recommended by some health care professionals to improve metabolic health and treat diabetes in adults.4–6 Carbohydrate restriction is often endorsed by celebrities, in popular diets, and in weight loss programs with testimonials on Web sites and social media.7 This clinical report reviews the evidence for low-carbohydrate diets in the treatment of children and adolescents with type 1 diabetes or obesity and prediabetes or type 2 diabetes.
What Children and Adolescents in the United States Are Eating
The American Academy of Pediatrics (AAP) recommends children aged 4 to 18 years get 10% to 30% of their total energy intake as protein to support normal growth and development, and 25% to 35% of energy intake come from fat, mostly from polyunsaturated and monounsaturated fatty acids and less than 10% from saturated fats.8 Carbohydrates then provide the remaining (45% to 65%) energy requirements, with the recommendation that not more than 10% of calories per day come from added sugars.9 It is recommended that most calories from carbohydrate come from fruits, vegetables, whole grains, legumes, and dairy products.10
The NHANES (NHANES 2017–2018) indicated self-reported dietary intakes for children and adolescents (2–19 years) reflect an energy distribution of approximately 51% from carbohydrate, 14% from protein, and 35% from fat.11 Multiple guidelines recommend dietary saturated fats be limited to 10% of total daily energy intake, but more than 85% of youth exceed this limit.10 Total sugars contribute more than 20% of calories per day, and most youth significantly exceed recommendations to limit added sugar to no more than 10% of calories.10 More than 70% of adolescents 14 to 18 years of age exceed limits of added sugar (247–277 kcal of added sugar per day).10 Dietary fiber intake, at an average of 14 g per day, is significantly lower than guidelines recommending at least 26 g dietary fiber in children 9 years and older.12 Lockdowns during the coronavirus disease 2019 (COVID-19) pandemic were associated with a decrease in diet quality for many youth.13 In a study of 3 schools in a single school district in the United States, the yearly BMI z-score change increased ∼10 times during the COVID-19 pandemic (+0.03 to +0.34 per year), the etiology of which is likely multifactorial and at least partly attributable to decreased diet quality.14
The degree to which food is processed contributes to the nutritional quality and macronutrient content of diets. Processed food refers to any food that has been altered from its natural state and is processed to be sold. Ultra-processed food products are made from ingredients and substances that are extracted from foods, such as starches, sugars, and fats, and generally contain low to no fiber. In addition to being physically processed to allow for consumption with minimal or no additional preparation, they contain multiple additives to improve color, flavor, and shelf-life and are packaged and sold for convenience. In people 2 years and older in the United States, more than 50% of the average daily energy intake comes from ultra-processed foods, and less than one-third of the average daily energy intake comes from unprocessed or minimally processed foods.15,16 Meat, fruit, and milk provide the most energy among unprocessed or minimally processed foods. Most of the carbohydrates eaten come from ultra-processed foods.15,16
Low-Carbohydrate Diets
There is no standard definition of high-, moderate-, low-, or very low-carbohydrate diets. Compared with the typically recommended diet containing 45% to 65% of total calories from carbohydrate, moderate carbohydrate restriction can be defined as 26% to 44% of total calories, whereas low- (<26%) and very low-carbohydrate (20–50 g per day) and ketogenic (<20 g per day) diets are further limited with regard to foods that can be included in the diet.5 Several academic and physician authors, as well as their patients, advocate for carbohydrate restriction as the principal approach for the treatment of type 2 diabetes and the most effective addition to insulin for managing blood glucose in patients with type 1 diabetes.5–7 There is evidence from adult studies that these diets can be associated with significant weight loss, reduction in insulin levels or insulin requirements, and improvement in glucose control.17–20 Nevertheless, there is a lack of long-term safety and efficacy outcomes in youth.
In pediatrics, ketogenic diets are used for the treatment of drug-resistant epilepsy, with the most reported adverse effects being vomiting, constipation, and diarrhea.21 There is a theoretical concern for negative impact of ketogenic diets on cognitive functioning, behavior, and mental health associated with undernutrition. However, ketogenic diets are not reported to have negative cognitive, behavioral, or mental health outcomes in youth with epilepsy.21 Confidence in the evidence for this may be weakened by the high attrition rate in therapeutic trials because of dietary intolerance or lack of observed efficacy. When using a ketogenic diet, extensive nutritional oversight is recommended, including working with a pediatric dietitian and supplementation with minerals and vitamin D and laboratory monitoring for safety.22 A significant amount of dietary restriction is required to maintain a low- or very low-carbohydrate diet, and therefore, long-term adherence is difficult for many who are prescribed this approach rather than choosing it themselves.
A principal concern associated with the ever-prevalent “diet culture” is the use of restrictive diets and development of disordered eating, particularly among youth with a negative body image.23 Body dissatisfaction associated with restrictive dieting practices places children and adolescents at risk for inadequate dietary intake, excessive weight gain resulting from binge-eating after restricting food intake, and use of harmful weight control strategies. Moreover, restrictive dieting practices may negatively impact mental health and self-concept and are directly associated with decreased mood and increased feelings of anxiety.23 There is consistent and abundant cross-sectional evidence of associations between unhealthy dietary patterns that lack nutrient-dense foods and worse mental health in childhood or adolescence, but whether this relationship is causal is unclear.24
Physiologic Rationale for Carbohydrate Reduction
Macronutrients in the gut and systemic circulation signal a digestive hormone, incretin, and insulin response.25 Insulin is an anabolic hormone that promotes growth and the repletion of energy stores. Although fat stores are typically plentiful in adipose tissue, sugars are not stored in unlimited supply in the body. Glucose is used for energy, with a limited amount of glycogen stored in muscle and liver. Excess glucose and other sugars are converted to lipids via de novo lipogenesis in the liver and stored as fat in the liver and adipose tissue. In times of fasting or limited carbohydrate intake, glycolysis and gluconeogenesis provide the body with glucose and ketone bodies are generated from glycerol (fat breakdown) and used for energy.
The insulin response to food ingestion promotes normal growth and anabolism. The action of insulin is to stimulate glucose uptake in skeletal muscle and liver, to promote fat storage, and to stimulate growth-promoting hormones. Resistance to the action of insulin at the level of the muscle or liver results in the need for increasing amounts of insulin to be released to maintain euglycemia. Insulin resistance is associated with obesity and genetic conditions of insulin resistance. Reducing the body’s requirement for insulin in these cases via decreased processed carbohydrate and sugar intake, weight loss, or increased physical activity can reduce insulin resistance.26–28 Because insulin action promotes fat storage, some have hypothesized that reducing insulin resistance also promotes weight loss regardless of calorie consumption, but this is controversial.20
Evidence for Carbohydrate Reduction in Youth With Type 1 Diabetes
Type 1 diabetes results from an absolute lack of insulin as a result of the autoimmune destruction of the pancreatic β-cells. Treatment necessitates exogenous insulin to provide the important anabolic effects for normal macronutrient metabolism, growth, and development.25 Before the discovery of insulin, type 1 diabetes was treated with a low-energy, very low-carbohydrate diet, and those with the disease during childhood had stunted growth and physical development.29 The response to a low-carbohydrate diet is to require less exogenous insulin, as carbohydrate consumption determines, to a large degree, the amount of insulin needed to maintain glucose at target levels. Insufficient insulin results in hyperglycemia, malnutrition, and poor growth. Regardless of dietary carbohydrate content, there is a physiologic amount of insulin required for normal metabolism, growth, and development.
Current dietary recommendations for children and adolescents with type 1 diabetes reflect those for the general population.29,30 It is standard to dose insulin at mealtimes according to the amount of carbohydrates to be eaten.30 People with type 1 diabetes may use lower carbohydrate diets to facilitate lowering exogenous insulin requirements and decrease blood glucose excursions associated with eating. However, there are very limited data to support the use of very low-carbohydrate or ketogenic diets in children and adolescents with type 1 diabetes. A study in adults with type 1 diabetes showed decreases in insulin requirements.31 A survey study was conducted with an international social media-based group of adults with type 1 diabetes and parents of youth with type 1 diabetes who choose to use low- or very low-carbohydrate diets as adjunct treatment.32 Respondents reported excellent glycemic control but poor relationships with diabetes care providers associated with distrust and feeling judged about their diabetes management decisions.32 Results of this survey suggest that health care provider-patient relationships would benefit from meeting families where they are, keeping in mind that there are a number of physiologic and psychological reasons to use caution with this approach in growing children and adolescents, and multidisciplinary surveillance is recommended (Table 1).30,33–41 Research is lacking to evaluate the mental health or behavioral outcomes associated with using carbohydrate-restricted diets in youth with type 1 diabetes.33,37 The use of very low-carbohydrate diets in children with type 1 diabetes has been reported to be associated with growth deceleration, hypoglycemia, abnormal lipid profile, risk for disordered eating, ketosis that may be nutritional but cannot be distinguished from ketosis resulting from insulin deficiency, and a theoretical concern for diabetic ketoacidosis.33–36 Thus, neither the American Diabetes Association nor the International Society for Pediatric and Adolescent Diabetes has endorsed the generalized use of low- or very low-carbohydrate diets in growing children and adolescents with type 1 diabetes.
Recommendations for Monitoring Children and Adolescents Who Elect to Follow a Very Low Carbohydrate Diet or Ketogenic Diet37
| Diet-associated Risk . | Monitoring Parameters . | Monitoring Frequency . | Additional Considerations for Children and Adolescents with Diabetes . | |
|---|---|---|---|---|
| Without Ketosis (20–50 g carb per day) . | With Ketosis (AM urine ketones > trace or blood ketones > 1.0) (<20 g carb per day) . | |||
| Growth deceleration | -Height, wt, BMI | Every 3–6 mo for first year; then every 6–12 mo. | Every 3–6 mo for first year; then every 6 mo. | Poor glycemic control exacerbates growth deceleration. |
| Pubertal delay | -Physical exam (until pubertal maturation is complete); -menstrual history | Every 3–6 mo for first year; then every 6-12 mo. | Every 3–6 mo for first year; then every 6 mo. | Poor glycemic control is associated with pubertal delay or abnormal menses. |
| Nutritional | -Dietary assessment and education with dietician; -magnesium, zinc, selenium levels; -vitamin D levels | Meet with dietician at baseline and every 3–6 mo. | -Meet with dietician at baseline; at 1 mo; then every 3–6 mo. -Laboratories at 1 mo; then every 3 mo for the first year; then every 6 mo. | Increased risk for nutritional deficiencies. Recommend close follow-up with a pediatric diabetes educator and dietician associated with pediatric diabetes care team. |
| Metabolic | -CMP (acid-base status, liver and kidney function); -urinalysis (ketonuria, hematuria and proteinuria associated with renal calculi); -β-hydroxybutyrate (ketosis); -free and total carnitine (carnitine deficiency from carbohydrate restriction, fatigue, muscle weakness, liver, and heart problems; -CBC (anemia, increased risk for bleeding because of platelet dysfunction) | If concern for growth delay, pubertal delay, and according to symptoms. | At 1 mo; then every 3 mo for the first year; then every 6 mo. | Ketosis is indicative of insulin deficiency, with risk for diabetic ketoacidosis. Carbohydrate restriction reduces physiologic response to glucagon and increases hypoglycemia unawareness. Use of a continuous glucose monitor is recommended. Recommend close monitoring by diabetes specialty care team. Contact diabetes care team for sick day management. |
| Cardiovascular | -Fasting lipid panel (dyslipidemia) | Baseline if not screened previously; follow published screening algorithms for all children.38 | Baseline if not screened previously; after 3–6 mo on diet; annually while following diet. | Diabetes is a risk factor for cardiovascular disease; fasting lipid profile is recommended annually for youth with type 2 diabetes39 and every 3 y for youth with type 1 diabetes.40 |
| Bone health | -Calcium, phosphorus; -vitamin D; -urine calcium or creatinine ratio (hypercalciuria); -DEXA scan | If concern for growth delay, pubertal delay, nutritional deficiencies, and according to symptoms. | -At 1 mo; then every 3 mo for the first year; then every 3–6 mo. -DEXA scan recommended if >5 y of age and following ketogenic diet >2 y. | Diabetes is a risk factor for decreased bone health. |
| Disordered eating or rebound wt gain | -Significant wt gain or loss; -screening questions41 | At each visit | At each visit | Diabetes is a risk factor for disordered eating.30 Deliberate insulin omission is a form of disordered eating and should be assessed by a pediatric diabetes care team. Ketosis is indicative of insulin deficiency (or insulin omission), with risk for diabetic ketoacidosis. |
| Mental health | -Depression or anxiety symptoms | Baseline if not screened previously; follow published screening algorithms for all children.38 | Baseline if not screened previously; after 3–6 mo on diet; annually while following diet. | Burdens of diabetes self-care impact quality of life and increase risk for depressive symptoms or anxiety. Depression and anxiety are associated with neglect of diabetes self-care. |
| Diet-associated Risk . | Monitoring Parameters . | Monitoring Frequency . | Additional Considerations for Children and Adolescents with Diabetes . | |
|---|---|---|---|---|
| Without Ketosis (20–50 g carb per day) . | With Ketosis (AM urine ketones > trace or blood ketones > 1.0) (<20 g carb per day) . | |||
| Growth deceleration | -Height, wt, BMI | Every 3–6 mo for first year; then every 6–12 mo. | Every 3–6 mo for first year; then every 6 mo. | Poor glycemic control exacerbates growth deceleration. |
| Pubertal delay | -Physical exam (until pubertal maturation is complete); -menstrual history | Every 3–6 mo for first year; then every 6-12 mo. | Every 3–6 mo for first year; then every 6 mo. | Poor glycemic control is associated with pubertal delay or abnormal menses. |
| Nutritional | -Dietary assessment and education with dietician; -magnesium, zinc, selenium levels; -vitamin D levels | Meet with dietician at baseline and every 3–6 mo. | -Meet with dietician at baseline; at 1 mo; then every 3–6 mo. -Laboratories at 1 mo; then every 3 mo for the first year; then every 6 mo. | Increased risk for nutritional deficiencies. Recommend close follow-up with a pediatric diabetes educator and dietician associated with pediatric diabetes care team. |
| Metabolic | -CMP (acid-base status, liver and kidney function); -urinalysis (ketonuria, hematuria and proteinuria associated with renal calculi); -β-hydroxybutyrate (ketosis); -free and total carnitine (carnitine deficiency from carbohydrate restriction, fatigue, muscle weakness, liver, and heart problems; -CBC (anemia, increased risk for bleeding because of platelet dysfunction) | If concern for growth delay, pubertal delay, and according to symptoms. | At 1 mo; then every 3 mo for the first year; then every 6 mo. | Ketosis is indicative of insulin deficiency, with risk for diabetic ketoacidosis. Carbohydrate restriction reduces physiologic response to glucagon and increases hypoglycemia unawareness. Use of a continuous glucose monitor is recommended. Recommend close monitoring by diabetes specialty care team. Contact diabetes care team for sick day management. |
| Cardiovascular | -Fasting lipid panel (dyslipidemia) | Baseline if not screened previously; follow published screening algorithms for all children.38 | Baseline if not screened previously; after 3–6 mo on diet; annually while following diet. | Diabetes is a risk factor for cardiovascular disease; fasting lipid profile is recommended annually for youth with type 2 diabetes39 and every 3 y for youth with type 1 diabetes.40 |
| Bone health | -Calcium, phosphorus; -vitamin D; -urine calcium or creatinine ratio (hypercalciuria); -DEXA scan | If concern for growth delay, pubertal delay, nutritional deficiencies, and according to symptoms. | -At 1 mo; then every 3 mo for the first year; then every 3–6 mo. -DEXA scan recommended if >5 y of age and following ketogenic diet >2 y. | Diabetes is a risk factor for decreased bone health. |
| Disordered eating or rebound wt gain | -Significant wt gain or loss; -screening questions41 | At each visit | At each visit | Diabetes is a risk factor for disordered eating.30 Deliberate insulin omission is a form of disordered eating and should be assessed by a pediatric diabetes care team. Ketosis is indicative of insulin deficiency (or insulin omission), with risk for diabetic ketoacidosis. |
| Mental health | -Depression or anxiety symptoms | Baseline if not screened previously; follow published screening algorithms for all children.38 | Baseline if not screened previously; after 3–6 mo on diet; annually while following diet. | Burdens of diabetes self-care impact quality of life and increase risk for depressive symptoms or anxiety. Depression and anxiety are associated with neglect of diabetes self-care. |
DEXA, dual-energy x-ray absorptiometry.
There is clinical consensus to support lower carbohydrate intake (26% to 40% energy) and higher protein intake and higher-quality fat intake in youth under medical supervision, if this is their choice and they have family and medical support.30,33,37 Maintaining open dialogue about diabetes management decisions, dietary habits and choices, and encouraging regular medical follow-up with a supportive multidisciplinary team, including a pediatric dietitian, is recommended. Guidelines for monitoring youth who choose to follow a low-carbohydrate diet have been proposed by a pediatric diabetes center.37 Nutritional ketosis has implications for growth and development, nutritional deficiencies, and metabolic, cardiovascular, and bone health, with added risk for patients with diabetes. Table 1 includes screening recommendations based on published guidelines for monitoring children and adolescents who follow a very low carbohydrate- or ketogenic diet. Children with diabetes (type 1 or type 2) should be followed closely by a pediatric endocrinologist and multidisciplinary diabetes specialty team.
Medical support is recommended to include a discussion of strategies to decrease postprandial glycemic excursions with a focus on adequate insulin dosing, ensuring adequate calories, and careful monitoring of growth, glycemic control, and secondary health outcomes (bone health, lipids, trace mineral status, metabolic profile, and blood counts).37 When calories from carbohydrates are limited, it is recommended that saturated fats are replaced with polyunsaturated and monounsaturated fats. In countries where the Mediterranean diet is the norm, up to 40% of energy may be from monounsaturated fat with no adverse impact on health outcomes.42
Evidence for Carbohydrate Reduction in Youth With Type 2 Diabetes
Type 2 diabetes results from resistance to the physiologic action of insulin in muscle and liver and progressive pancreatic β-cell failure resulting in relative insulin deficiency. Treatment necessitates addressing insulin resistance and deficiency. Carbohydrate reduction can be an important and effective part of overall treatment of type 2 diabetes, reducing insulin resistance and the demand on the pancreas for increasing amounts of insulin.30,43 As is the case for persons with type 1 diabetes, persons with type 2 diabetes who use exogenous insulin for treatment may use lower carbohydrate diets to lower blood glucose values and decrease exogenous insulin requirements.
There is benefit for blood glucose and cardiovascular disease risk outcomes associated with moderate- or low-carbohydrate diets in adults with type 2 diabetes,43 but research and published literature on the use of carbohydrate restricted diets pertinent to youth with type 2 diabetes is very limited.44 A retrospective chart review of youth with type 2 diabetes who followed a ketogenic, very low-calorie diet for a mean of 60±8 days found that patients who followed the diet plan had short-term diabetes remission and decreased BMI for at least 6 weeks compared with patients not following the diet.45 Long-term outcomes of youth following carbohydrate-restricted diets on diabetes and cardiovascular outcomes are needed and may be underreported because of attrition.44 The AAP recommends that youth with type 2 diabetes who choose to follow a low- or very low-carbohydrate diet are monitored as described above for youth with type 1 diabetes and work with a pediatric dietitian.37
There is an abundance of evidence that reducing carbohydrate intake from added sugars and processed foods is associated with better obesity, diabetes, and cardiovascular health outcomes.3,9 Youth with type 2 diabetes are at significantly increased risk for the development of cardiovascular disease and microvascular complications associated with hyperglycemia.3 Reduction of simple carbohydrate intake is strongly recommended to minimize glycemic excursions.3,46 Dietary changes, which include the reduction of simple sugars, sugar-sweetened beverages, juices, and highly processed foods in persons with insulin resistance and type 2 diabetes, can be highly impactful with positive benefits for weight management, lipid profile, insulin sensitivity, and glycemic control.46–49
A significant proportion (32% to 59%) of youth with type 2 diabetes live in socially disadvantaged and impoverished environments, which contribute to poor diet quality.50–55 Barriers to the implementation of these nutrition recommendations include food insecurity, disparities in access to health care services, and lack of support and resources to aid in making behavioral lifestyle changes. Pediatricians can advocate for and encourage enrollment in federal nutrition programs, which help to alleviate food insecurity.56 Participation in federal nutrition programs is associated with lower rates of obesity and better health outcomes.57
Evidence for Carbohydrate Reduction as a Strategy for Diabetes Prevention
Diet strategies to restrict fat intake have long been recommended for the prevention of diabetes and cardiovascular disease.58–60 The highly effective Diabetes Prevention Program used a lifestyle intervention that recommended a low-fat and standard carbohydrate diet strategy with the goal of achieving at least 7% weight loss and at least 150 minutes of physical activity per week in adults meeting laboratory criteria for impaired glucose tolerance (prediabetes).61 In addition to dietary change, regular physical activity decreases insulin resistance, improves glucose tolerance, and is a major component of diabetes prevention interventions.61–63 Low-carbohydrate diet programs have reported success with diabetes prevention but have not been studied or reported with equivalent rigor.62 It is now accepted that there are multiple diet strategies and programs associated with moderate weight loss that promote diabetes prevention in adult populations.63
Although few, studies to date in youth have shown no differences in weight loss when comparing calorie-restricted low-fat or low-carbohydrate diets and indicate that a reduced energy diet irrespective of macronutrient breakdown was most important for achieving weight loss.64–66 Thus, research to date indicates that any eating plan that provides nutritional requirements for normal growth and development and results in longer-term weight management may promote the prevention of diabetes; therefore, personalization and support to choose a plan that fits individual needs is key.60,62,67,68 In addition to nutrition recommendations, diabetes prevention in youth includes minimizing sedentary behaviors and increasing moderate to vigorous physical activity to 60 minutes or more per day.43,69
Evidence for Focus on Dietary Patterns Rather Than Macronutrients
Dietary patterns that emphasize plant-based foods (vegetables, fruits, whole-grains), lean sources of protein (poultry, fish, legumes), mono- and polyunsaturated fats, and low-fat dairy products and that limit sugary beverages and highly processed foods are associated with better long-term health outcomes, as shown in studies of diets such as the Mediterranean diet and Dietary Approaches to Stop Hypertension (DASH).59 There is a paucity of data in youth with diabetes or with obesity who follow a Mediterranean diet pattern. However, there is an abundance of evidence that a Mediterranean diet pattern with increased intake of olive oil (monounsaturated fat) is beneficial for glycemic and health outcomes in adults with diabetes.70 This diet pattern high in monounsaturated fatty acids, when compared with diets high in carbohydrates or high in polyunsaturated fatty acids, is associated with lower glucose, total cholesterol (higher high-density lipoprotein), triglycerides, body weight, and blood pressure in adults with type 2 diabetes.71 Similarly, the dietary pattern recommended in the Dietary Guidelines for Americans (high in fiber, low in saturated fat) is associated with better glycemic and cardiometabolic risk profiles.72
There may be barriers to the implementation of the recommendations in this clinical report. In some cases, nutrition education is not adequate during the training of health care professionals. Time for routine and disease-specific nutrition counseling for obesity, prediabetes, and diabetes in pediatric practice is limited. Moreover, referral resources to assist with the management of these conditions are not readily available or covered by most health insurance plans. Not only is there a lack of payment for counseling, but there may be a perception—or it may be reality—that patients and families lack interest or time for making dietary changes.73
Practical Strategies for Reducing Processed Carbohydrates and Added Sugars
Most families understand that eating or drinking too much sugar is not healthy but do not know how to identify added sugars or are confused about making sense of nutrition labels. Educating families, children, and adolescents about using the Nutrition Facts Label on processed foods to make healthy food choices is supported by the AAP, with resources available for pediatricians.74 It is important to meet families where they are and assess what they are currently doing and where they are open to change.75 First, routinely ask about all the beverages consumed (pop, soda, sports drinks, coffee or tea drinks, juices, waters, purchased drinks, milks). If families, children, or adolescents are consuming sugary beverages, begin there, with asking about the possibility of reducing and move toward eliminating sugary beverages. Artificial or nonnutritive sweeteners are considered suitable substitutes when used in moderation for sugar-sweetened drinks in children and adolescents with diabetes. It is the job of pediatricians and other pediatric health care professionals to inform families that sugary drinks promote weight gain and diabetes and do not provide nutritional value,46 while realizing that these are individual and family decisions and that families value support in making lifestyle changes. Support for behavior change can include asking about a few small changes the individual or family is willing to make to reduce added sugars in drinks and foods, documenting these, and following up on these at a planned visit. If sugary beverages are not a problem, packaged snacks or portion sizes of processed or high-carbohydrate, low-nutrient foods can be addressed similarly. In practice, pediatricians often record estimates of grams of carbohydrate eaten from dietary recall and help families make a goal to limit carbohydrate to a lower number of grams per day or per meal than their baseline if they are overeating. For example, if an adolescent is eating 150 to 200 g of carbohydrate per meal, carbohydrate counting (grams of carbohydrate) would be recommended to limit meals to 100 to 150 g of carbohydrate and increase servings of vegetables for the first step.
Conclusions
There is a paucity of data on dietary patterns to reduce risk for diabetes or manage diabetes in youth. Published evidence and guidelines point to use of a balanced dietary pattern such as that recommended in the Dietary Guidelines for Americans, increasing dietary fiber, and reducing the consumption of ultra-processed carbohydrates. Nevertheless, there is interest and limited anecdotal and published evidence that carbohydrate restriction can help to improve glycemic and metabolic profiles in youth with type 1 diabetes or obesity, prediabetes, and type 2 diabetes. Despite the increasing popularity of low-carbohydrate and ketogenic diets for managing diabetes in adults, there are safety concerns to consider for youth with diabetes who are restricting carbohydrate intake to control weight and/or blood glucose. These include growth deceleration, nutritional deficiencies, poor bone health, nutritional ketosis that cannot be distinguished from ketosis resulting from insulin deficiency, and disordered eating behaviors.
Low-carbohydrate (<26% energy) and very low-carbohydrate (20–50 g) diets are not recommended for children and adolescents with type 1 diabetes, except under close diabetes care team supervision utilizing safety guidelines.37
Reducing nutrient-poor carbohydrate intake by minimizing the consumption of processed foods with high amounts of refined grains and added sugars and eliminating sugar-sweetened beverages is recommended for the prevention and treatment of prediabetes and type 2 diabetes.43,62
Eliminating sugary beverages and juices significantly improves blood glucose and weight management in children and adolescents.46
Dietary restriction of any kind can be associated with physical, metabolic, and psychological consequences, including risk for disordered eating in children and adolescents, with additional risk for those with diabetes. It is advised that pediatricians and pediatric specialty care providers work together with patients and families who choose to use carbohydrate restriction to promote regular medical follow-up according to published guidelines (Table 1).37
Pediatricians can counsel youth with type 1 diabetes, prediabetes, or type 2 diabetes for whom weight loss or maintenance is medically indicated that a reduced-energy diet, irrespective of carbohydrate content, is most important for achieving weight loss.
Families of children and adolescents with type 1 diabetes, prediabetes, or type 2 diabetes may be counseled to follow a healthy dietary pattern strategy (ie, Mediterranean diet, Dietary Guidelines for Americans) and strive for 60 minutes per day of moderate to vigorous aerobic activity to reduce obesity, improve diabetes-related health outcomes, and promote optimal glycemic and cardiometabolic outcomes.8,62
Patients who have socioeconomic disadvantages are at increased risk for prediabetes and type 2 diabetes and face barriers to following Dietary Guidelines for Americans and restricting processed foods. Pediatricians can advocate for policies to protect and strengthen federal, state, and local nutrition programs and encourage families who qualify for federal nutrition programs to participate in them to improve dietary intake and quality. Addressing Food Insecurity: A Toolkit for Pediatricians is available at https://frac.org/aaptoolkit.52
Resources
Dietary Guidelines for Americans (https://www.dietaryguidelines.gov)
US Department of Agriculture (USDA) MyPlate (https://www.myplate.gov)
Serving Up Good Nutrition: Sample Menus, Portion Sizes, and Why It Matters (https://shop.aap.org/serving-up-good-nutrition-brochure)
AAP PediaLink: Talking to Parents and Patients About Using the Nutrition Facts Label to Make Healthy Food Choices (https://shop.aap.org/talking-to-parents-and-patients-about-using-the-nutrition-facts-label-to-make-healthy-food-choices)
Addressing Food Insecurity: A Toolkit for Pediatricians is available at https://frac.org/aaptoolkit
Lead Authors
Anna Neyman, MD, FAAP
Tamara S. Hannon, MD, FAAP
Committee on Nutrition, 2021–2022
Mark R. Corkins, MD, FAAP, Chairperson
Cynthia L. Blanco, MD, FAAP
George J. Fuchs, III, MD, FAAP
Praveen S. Goday, MD, FAAP
Tamara S. Hannon, MD, FAAP
C. Wesley Lindsey, MD, FAAP
Ellen S. Rome, MD, MPH, FAAP
Liaisons
Andrew Bremer, MD, PhD, FAAP – National Institutes of Health
Andrea Lotze, MD, FAAP – US Food and Drug Administration
Cria Perrine, PhD – Centers for Disease Control and Prevention
Ana Sant’Anna, MD – Canadian Pediatric Society
Cheryl Funanich, MEd, RD, LD – US Department of Agriculture
Staff
Debra L. Burrowes, MHA
Dr Neyman completed the literature review, interpreted the data, and wrote the manuscript; and Dr Hannon reviewed the literature review, wrote, and edited the manuscript, and supervised the project.
Clinical reports from the American Academy of Pediatrics benefit from expertise and resources of liaisons and internal (AAP) and external reviewers. However, clinical reports from the American Academy of Pediatrics may not reflect the views of the liaisons or the organizations or government agencies that they represent.
The guidance in this report does not indicate an exclusive course of treatment or serve as a standard of medical care. Variations, taking into account individual circumstances, may be appropriate.
All clinical reports from the American Academy of Pediatrics automatically expire 5 years after publication unless reaffirmed, revised, or retired at or before that time.
This document is copyrighted and is property of the American Academy of Pediatrics and its Board of Directors. All authors have filed conflict of interest statements with the American Academy of Pediatrics. Any conflicts have been resolved through a process approved by the Board of Directors. The American Academy of Pediatrics has neither solicited nor accepted any commercial involvement in the development of the content of this publication.
Comments
Letter to the Editor
The pandemic of metabolic diseases which includes obesity, diabetes and MAFLD has risen at an alarming rate in the adult and pediatric populations. We applaud the American Academy of Pediatrics for including therapeutic carbohydrate reduction (TCR) for the treatment of prediabetes and type 2 diabetes in their recent consensus statement. Their support for TCR in a supervised medical setting is a welcome message, and is in line with the adult recommendations from the American Diabetes Association. [1]
Our concerns about this consensus statement relate to the common confusion of TCR with the “ketogenic diet for childhood epilepsy.” TCR is much less restrictive than the classic 4:1 “ketogenic diet,” so the reference to growth or rare adverse events of 4:1 ketogenic diets do not apply. [2]. This conflation has also perpetuated several biases against TCR regarding its effects on growth and development and eating disorders.
The consensus statement erroneously stated that insulin will not be available for growth and development for those following a TCR diet. Actually, those with type 1 diabetes on a TCR diet still require exogenous insulin—just less insulin than before, so growth and development and normoglycemia are possible at the same time. A recent study of a very low carb diet in individuals affected by type 1 diabetes showed no signal of growth reduction. [2] Numerous studies show that elevated A1cs are typical of children with type 1 diabetes following the standard carbohydrate-emphasized diet, and are also responsible for reducing growth and causing damage to the developing child brain. [3,4]
Third, the concerns about eating disorders do not take into account the literature showing elevated hemoglobin A1cs, typical of those with type 1 diabetes, are correlated with eating disorders and a low diet quality.[5] An important feature of well-formulated TCR diets is improving diet quality through the reduction of ultra-processed, high-glycemic foods, which themselves are implicated in disordered eating.
It is our conclusion that the literature allows for an opposite conclusion: TCR may be the best approach for children affected by diabetes. TCR is associated with an average hemoglobin A1c of 5.7% in adherent participants.[2] Given this unprecedented efficacy and the inappropriate comparison to the “ketogenic diet for childhood epilepsy,” we wonder if unnecessary harm and bias may be created by the AAP position statement.
Acknowledgements
The authors reported no funding received for this work.
TK is an unpaid member of the Board of Directors of the Society of Metabolic Health Practitioners and a producer of podcasts on health and nutrition, with all proceeds donated to humanitarian charities; his spouse has ownership interest in a food company. ECW is an unpaid member of the Board of Directors of the Society of Metabolic Health Practitioners, receives royalties for the sale of diet books, and has equity in Adapt Your Life, Inc., a company based on low-carbohydrate concepts.
Contributor Information
David Dikeman, Student, Baylor University.
Tro Kalayjian, Private practice, Tappan, NY, USA.
Eric C Westman, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
References
[1] Evert AB, Dennison M, Gardner CD et al. Nutrition therapy for adults with diabetes or prediabetes: A consensus report. Diabetes Care. 2019 May;42(5):731-754
[2] Lennerz BS, Barton A, Bernstein RK et al. Management of type 1 diabetes with a very low-carbohydrate diet. Pediatrics. 2018 Jun;141(6):e20173349.
[3] Bonfig W, Kapellen T, Dost A, et al. Growth in children and adolescents with type 1 diabetes. J Pediatr. Jun; 2012 160(6):900–903 e902.
[4] Mazaika PK, Weinzimer SA, Mauras N et al. Diabetes research in children network (DirecNet). Variations in brain volume and growth in young children with type 1 diabetes. Diabetes. 2016 Feb;65(2):476-85.
[5] Eisenberg Colman MH, Quick VM, Lipsky LM et al. Disordered eating behaviors are not increased by an intervention to improve diet quality but are associated with poorer glycemic control among youth with type 1 diabetes. Diabetes Care. 2018 Apr;41(4):869-875.
4:1 Keto Diets are not Well Formulated Ketogenic Diets
Unfortunately, the authors conflated 4:1 ketogenic diets used to treat epilepsy with well-formulated TCR diets used to treat metabolic disease. Therapeutic ketogenic diets for epilepsy are generally 4:1 or 3:1, where there are 4 grams or 3 grams of fat for every 1 gram of protein and carbohydrate, respectively. For a 4:1 ketogenic diet, this equates to 90% of calories from fat.
These 4:1 diets have never been recommended for treatment of metabolic disease, which is the topic of this report. The low carbohydrate eating pattern used to treat metabolic disease can be called “well formulated TCR” and is more akin to a low carbohydrate Mediterranean diet than a 4:1 ketogenic diet. This eating pattern contains 70% of calories from fat, which is far less than the 90% seen in a 4:1 ketogenic diet. Indeed, a popular well-formulated TCR allows for 3 cups of vegetables, which fulfills the AAP’s recommended 5 servings of vegetables per day through age 18 [1].
It is true that strict 4:1 ketogenic diets have been historically implicated with carnitine deficiency. However, well formulated TCR has a protein content of 20-30% from sources rich in carnitine. To date, there have been no cases of carnitine deficiency in adult or pediatric literature on well formulated TCR. This conflation of 4:1 ketogenic diet risks are repeated in the citations for growth, bone health, nephrolithiasis, and micronutrient deficiencies. The AAP needlessly medicalizes one of the most nutrient dense pattern of eating that is available to children- a dietary pattern rich in high quality animal protein, natural fats, and vegetables.
The authors also cite concerns regarding eating disorders and TCR. Including 4:1 ketogenic diet data, we have over a century of data on medical lifestyle changes, and there is no evidence that clinician-recommended nutritional interventions focusing on health promote eating disorders. The authors cite a study about diet culture which is nonspecific and would make the Mediterranean diet or vegetarianism at risk for causing eating disorders [2]. Another citation from the report actually states “the role of low carbohydrate diets per se has not been clearly established as a predictor of an eating disorder.” [3]
Furthermore, the AHA and ADA both report that TCR is reasonable to treat T2DM in adults [4]. The ADA states that “reducing overall carbohydrate intake for individuals with diabetes has demonstrated the most evidence for improving glycemia....” [5]. The AAP has a remarkable opportunity to follow in the ADA’s footsteps and be evidenced based with dietary treatments for pediatric diabetes and in those at risk of diabetes. For that to happen, we need to move forward on common ground with correct terminology.