School-aged children experienced substantial challenges to health and well-being as a result of school building closures, due to the coronavirus disease 2019 (COVID-19) pandemic. In hopes of supporting equitable and safe school reopening for every student across North Carolina (NC) and improve child health, researchers from Duke University and the University at North Carolina at Chapel Hill established the ABC Science Collaborative (ABCs) in July 2020. The ABCs collected data related to in-school severe acute respiratory syndrome coronavirus 2 transmission and adherence to mitigation strategies. This data was presented to NC government officials, including the NC Department of Health and Human Services, the NC Department of Public Instruction, and Democratic and Republican representatives from the NC General Assembly. These data-sharing practices led to the implementation of in-person school legislation in early 2021 that required in-person school access for every student, supported the full-time in-person reopening of NC public schools, and required weekly reporting to the ABCs of COVID-19 infections from more than 1,000,000 children and adults.

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