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Synopsis Book: Best Articles Relevant to Pediatric Allergy, Asthma and Immunology

Supplement Article

Title Page

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Section on Allergy and Immunology

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Topics: allergy and immunology

About This Synopsis Book

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Topics: allergy and immunology , hypersensitivity , asthma , care of intensive care unit patient

A Synopsis of the Synopses, 2021–2022

Julie Wang, MD, FAAP

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Topics: clinical diagnostic instrument , exposure , hypersensitivity , immune system diseases , comorbidity

Allergy

Risk Factors and Prevention of Atopy

Infant Gut Microbiome is Enriched with Bifidobacterium longum ssp. infantis in Old Order Mennonites With Traditional Farming Lifestyle

Elinor Simons, MD, PhD

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Topics: bifidobacterium longum , intestinal bacteria , life style , geographic population

Increased Food Diversity in the First Year of Life is Inversely Associated with Allergic Outcomes in the Second Year

Devika Pillay, DO; Kyle Robillard, MD; Elizabeth C. Matsui, MD, MHS

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Topics: food , hypersensitivity , geographic population

Inverse Associations Between Food Diversity in the Second Year of Life and Allergic Diseases

Russell Behmer, MD; Theresa Bingemann, MD

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Topics: food , hypersensitivity , geographic population

Increasing Severity of Early-onset Atopic Dermatitis, but Not Late-onset, Associates With Development of Aeroallergen Sensitization and Allergic Rhinitis in Childhood

Yatyng Chang, MD; Vivian P Hernandez-Trujillo, MD

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Topics: allergic rhinitis , atopic dermatitis , sensitization

Effect of Vitamin D Supplementation on Total and Allergen-specific IgE in Children With Asthma and Low Vitamin D Levels

Tevon Hood, DO; Pooja Varshney, MD

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Topics: allergens , asthma, childhood , immunoglobulin e , vitamin d

Prevalence of Type 2 Inflammatory Diseases in Pediatric Patients With Atopic Dermatitis: Real-world Evidence

Paulina Tran, DO; Terri Brown-Whitehorn, MD

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Topics: atopic dermatitis , inflammatory disorders

Increased Risk of Asthma at Age 10 Years for Children Sensitized to Multiple Allergens

Lauren Davidson, MD; Theresa Bingemann, MD

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Topics: allergens , asthma , geographic population

Anaphylaxis

Use of Multiple Epinephrine Doses in Anaphylaxis: A Systematic Review and Meta-analysis

Mitchell R. Lester, MD

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Topics: anaphylaxis , epinephrine

Anaphylaxis and Pregnancy: A Systematic Review and Call for Public Health Actions

Levi S. Marshall, MD; Karla L. Davis, MD

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Topics: anaphylaxis , public health medicine

Drug Allergy

Establishing Amoxicillin Allergy in Children Through Direct Graded Challenge (GOC): Evaluating Risks Factors for Positive Challenges, Safety, and Risk of Cross-Reactivity to Cephalosporins

Paul Williams, MD

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Topics: amoxicillin , cephalosporins , cross reactions , hypersensitivity

Safety and Efficacy of Rapid Drug Desensitization in Children

Naiya B. Patel, MD; Christopher Parrish, MD

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Topics: desensitization , geographic population , receptor desensitization , sinus histiocytosis , dirty bombs

Single-step Direct Drug Provocation Testing is Safe for Delabelling Selected Non−low-risk Penicillin Allergy Labels

John M. Kelso, MD

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Topics: penicillin allergy , amoxicillin

Toxic Epidermal Necrolysis and Stevens-Johnson Syndrome or Toxic Epidermal Necrolysis Overlap in Pediatric Patients With a Focus on Newer Antiepileptic Drugs: A 25-year Retrospective Study at a Single Tertiary Care Center

Marcella Aquino, MD

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Topics: anticonvulsants , epidermal necrolysis, toxic , stevens-johnson syndrome , tertiary care hospitals , geographic population

Allergic Rhinitis

Obesity Can Contribute to Severe Persistent Allergic Rhinitis in Children Through Leptin and Interleukin-1 β

Stuart L. Abramson, MD, PhD

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Topics: allergic rhinitis , interleukin-1 , leptin , obesity , persistence

Efficacy of Medical Treatments for Vernal Keratoconjunctivitis: A Systematic Review and Meta-analysis

Mitchell R. Lester, MD

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Topics: keratoconjunctivitis, vernal , geographic population

Risk Factors for Fatal and Nonfatal Reactions to Immunotherapy (2008–2018): Postinjection Monitoring and Severe Asthma

John M. Kelso, MD

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Topics: asthma , immunotherapy

Allergic Skin Diseases

Atopic Dermatitis Trajectories to Age 8 Years in the GUSTO Cohort

Mary V. Lasley, MD

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Topics: atopic dermatitis , wheezing , geographic population

Childhood Atopic Dermatitis is Associated With Cognitive Dysfunction: A National Health Interview Survey Study From 2008 to 2018

John M. Kelso, MD

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Topics: atopic dermatitis , cognitive impairment , national health interview survey , geographic population

Parent Report of Sleep Health and Attention Regulation in a Cross-sectional Study of Infants and Preschool-aged Children With Atopic Dermatitis

Marcella Aquino, MD

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Topics: atopic dermatitis , cross-sectional studies , parent report measures , preschools , sleep

Vascular Inflammation in Moderate-to-Severe Atopic Dermatitis is Associated With Enhanced Th2 Response

Elinor Simons, MD, PhD

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Topics: atopic dermatitis , inflammation

Efficacy and Safety of Ruxolitinib Cream for the Treatment of Atopic Dermatitis: Results From 2 Phase 3, Randomized, Double-blind Studies

Colleen Moran Shannon, MD; Terri Brown-Whitehorn, MD

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Topics: atopic dermatitis , cream , double-blind method , ruxolitinib

Age-related Differences in Patch Testing Results Among Children: Analysis of North American Contact Dermatitis Group Data, 2001–2018

Kim Nguyen, MD; Terri Brown-Whitehorn, MD

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Topics: contact dermatitis , patch tests

Food Allergy

IgE-Mediated Food Allergy

African American Children Are More Likely to Be Allergic to Shellfish and Finfish: Findings From FORWARD, a Multisite Cohort Study

Ashley Lee, MD; Scott Sicherer, MD

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Topics: african american , shellfish allergy , food allergy , geographic population

Natural History of IgE-Mediated Fish Allergy in Children

Ashley Lee, MD; Scott Sicherer, MD

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Topics: fish allergy , immunoglobulin e

Characterizing Biphasic Food-Related Allergic Reactions Through a US Food Allergy Patient Registry

Paul Williams, MD

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Topics: food , food allergy , hypersensitivity , geographic population

Food Proteins in Human Breast Milk and Probability of IgE-Mediated Allergic Reaction in Children During Breast-feeding: A Systemic Review

Karen S. Hsu Blatman, MD; Marcus Shaker, MD, MSc

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Topics: breast feeding , food , hypersensitivity , immunoglobulin e , milk, human

Doses of Specific Allergens in Early Introduction Foods for Prevention of Food Allergy

Karla L. Davis, MD

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Topics: allergens , food , food allergy

Diagnostic Accuracy of Ara h 2 for Detecting Peanut Allergy in Children

Sana Patel, MD; Mary V. Lasley, MD

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Topics: peanut hypersensitivity , peanuts , kuwait , immunoglobulin e

Accurate and Reproducible Diagnosis of Peanut Allergy using Epitope Mapping

James R Banks, MD; Timothy Andrews, MD

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Topics: epitope mapping , peanut hypersensitivity

Development and Validation of the Food Allergy Severity Score

Yatyng Chang, MD; Vivian P Hernandez-Trujillo, MD

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Topics: food allergy

Peanut Cross-contamination in Randomly Selected Baked Goods

Lauren Franzblau, MD; Jeffery Chambliss, MD

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Topics: peanuts , geographic population

Differences in Oral Food Challenge Reaction Severity Based on Increasing Age in a Pediatric Population

Eric Jorgensen, MD; Theresa A. Bingemann, MD

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Topics: food , geographic population

Tolerance Development in Cow’s Milk-allergic Infants Receiving Amino-acid Based Formula: A Randomized Controlled Trial

Sarah Campbell, MD; Pooja Varshney, MD

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Topics: amino acids , milk , geographic population

Efficacy and Safety of Oral Immunotherapy in Children Aged 1 to 3 Years With Peanut Allergy (the Immune Tolerance Network IMPACT Trial): A Randomized Placebo-Controlled Study

Gaytri Patel, MD; J. Andrew Bird, MD

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Topics: immune tolerance , immunotherapy , impact trial , peanut hypersensitivity , disease remission

Real-world Peanut OIT in Infants May be Safer than Noninfant Preschool OIT and Equally Effective

Sarah W. Hughes, MPAS, PA-C; Marcus Shaker, MD, MSc

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Topics: peanuts , preschools , preschool child , geographic population

Open-label Follow-on Study Evaluating the Efficacy, Safety, and Quality of Life With Extended Daily Oral Immunotherapy in Children With Peanut Allergy

Yatyng Chang, MD; Vivian P Hernandez-Trujillo, MD

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Topics: immunotherapy , peanut hypersensitivity , quality of life , geographic population , food allergy

Efficacy and Safety of Baked Milk Oral Immunotherapy in Children With Severe Milk Allergy: A Randomized, Double-blind, Placebo-controlled Phase 2 Trial

Dieu Doan, MD; Akilah A. Jefferson, MD, MSc

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Topics: immunotherapy , milk , milk hypersensitivity , hypersensitivity , geographic population

Non-IgE Mediated Food Allergy

Frequency of Guideline-defined Cow's Milk Allergy Symptoms in Infants: Secondary Analysis of EAT Trial Data

Shifaa Alkotob, MD; Girish Vitalpur, MD

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Topics: cow's milk , hypersensitivity , secondary data analysis

The Effects of Patient Demographics on Outpatient Endoscopy Utilization in Children With Eosinophilic Esophagitis

Shruti Sakhuja, MD; Anthony P. Olive, MD; Eric H. Chiou, MD

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Topics: endoscopy , eosinophilic esophagitis , outpatients , demography

Neonatal Antibiotics and Food Allergy are Associated With FGIDs at 4 to 6 Years of Age

Isha Kaul, MD; Sara Anvari, MS, MD; Carla Davis, MD

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Topics: food allergy , newborn , geographic population

Asthma

Epidemiology and Risk Factors

Childhood Asthma Incidence, Early and Persistent Wheeze, and Neighborhood Socioeconomic Factors in the ECHO/CREW Consortium

Kristin Kan, MD, MPH, MSc; Ruchi S. Gupta, MD, MPH

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Topics: asthma, childhood , echocardiography , neighborhood , persistence , wheezing

US Childhood Asthma Incidence Rate Patterns From the ECHO Consortium to Identify High-risk Groups for Primary Prevention

Shouling Zhang, MD; Julie Wang, MD

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Topics: asthma, childhood , echocardiography , primary prevention , asthma , geographic population

Worldwide Trends in the Burden of Asthma Symptoms in School-aged Children: Global Asthma Network Phase I Cross-sectional Study

Smridhi Mahajan, MD; J. Andrew Bird, MD

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Topics: asthma , school-age child , trend , cross-sectional studies

Antibiotic Exposure During Pregnancy and Childhood Asthma: A National Birth Cohort Study Investigating Timing of Exposure and Mode of Delivery

Philip Mendez, DO, MPH; Angela Hogan, MD

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Topics: asthma, childhood , birth cohort , prenatal exposure

Evidence for Causal Associations Between Prenatal and Postnatal Antibiotic Exposure and Asthma in Children

Simran Jutla, MD; Girish Vitalpur, MD

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Topics: asthma, childhood , prenatal care

Association Between Asthma and Sugar-Sweetened Beverage Consumption in the United States Pediatric Population

David Van, MD; Andrew Abreo, MD

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Topics: asthma , sugar-sweetened beverages , asthma, childhood , geographic population

Fruit, Vegetable, and Dietary Antioxidant Intake in School Age, Respiratory Health up to Young Adulthood

Jenyfeer Blanco, MD; Girish V. Vitalpur, MD

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Topics: antioxidants , diet , fruit , vegetables , asthma

Childhood Food Allergy and Food Allergen Sensitisation are Associated With Adult Airways Disease: A Birth Cohort Study

Kyle Robillard, MD; Devika Pillay, DO; Elizabeth C. Matsui, MD, MHS

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Topics: airway device , allergens , birth cohort , food , food allergy

Intake of n-3 Polyunsaturated Fatty Acids in Childhood, FADS Genotype and Incident Asthma

Lily H. Nguyen, MD; Lindsey Moore, DO

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Topics: asthma , genotype , omega-3 fatty acids

High Insulin in Early Childhood Is Associated With Subsequent Asthma Risk Independent of Body Mass Index

Michael W. Tsoulis, MD, MSc; Marcus S. Shaker, MD, MSc

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Topics: asthma , body mass index procedure , insulin

Maternal Preconception Occupational Exposure to Cleaning Products and Disinfectants and Offspring Asthma

Tevon Hood, DO; Pooja Varshney, MD

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Topics: asthma , disinfectants , occupational exposure , offspring

Parental Socioeconomic Status and Asthma in Children: Using a Population-based Cohort and Family Design

Isaiah Ingram, MD; Girish Vitalpur, MD

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Topics: asthma , asthma, childhood , socioeconomic factors , geographic population

Late Preterm Infants With Severe Bronchiolitis and Risk of Asthma by Age 5 Years

Cassie Shaw, MD; Elizabeth Wisner, MD

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Topics: asthma , bronchiolitis , infant, premature

Pneumonia in Infancy and Risk for Asthma: The Role of Familial Confounding and Pneumococcal Vaccination

Kristina Roth, MD; Lindsey Moore, DO

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Topics: asthma , pneumococcal vaccine , pneumonia

Factors Associated With Persistence of Severe Asthma From Late Adolescence to Early Adulthood

Samantha K. Knox, MD; Todd A. Mahr, MD

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Topics: asthma

Diagnosis and Management

Implementing Spirometry and Fractional Exhaled Nitric Oxide Testing in Childhood Asthma Management in UK Primary Care: An Observational Study to Examine Training and Implementation Cost and Impact on Patient’s Health Use and Outcome

Victoria Shum, MD; Angela Hogan, MD

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Topics: asthma, childhood , exhaled nitric oxide , spirometry , united kingdom , urokinase

Association of Mold Levels in Urban Children’s Homes With Difficult-to-control Asthma

Nithya Koka, MD; Akilah A. Jefferson, MD, MSc

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Topics: asthma , mold

Effect of School Integrated Pest Management or Classroom Air Filter Purifiers on Asthma Symptoms in Students With Active Asthma: A Randomized Clinical Study

Alan B. Goldsobel, MD

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Topics: asthma , classroom , filters , pest control , allergens

Air Pollutants and Asthma Hospitalization in the Medicaid Population

Abeer Siddiqi, MD; Joyce E. Yu, MD

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Topics: air pollutants , asthma , medicaid

Thunderstorm Asthma in Seasonal Allergic Rhinitis: The TAISAR Study

Joshua Walls, MD; Akilah Jefferson, MD, MSc

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Topics: asthma , hay fever , geographic population

COVID-19 Pandemic-Related Reductions in Pediatric Asthma Exacerbations Corresponded With an Overall Decrease in Respiratory Viral Infections

Karla L. Davis, MD

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Topics: asthma, childhood , covid-19 , pandemics , virus diseases , asthma

Oncostatin M Expression Induced by Bacterial Triggers Drives Airway Inflammatory and Mucus Secretion in Severe Asthma

James E. Gern, MD

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Topics: airway device , airway structure , asthma , bodily secretions , mucus

Association Between Asthma Control Trajectories in Preschoolers and Disease Remission

Phil Mendez, DO, MPH; Victoria Shum, MD; Lindsey Moore, DO

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Topics: asthma management , disease remission , preschool child , asthma

Controller Medication Use and Exacerbations for Children and Adults With Asthma in High-Deductible Health Plans

Shouling Zhang, MD; Julie Wang, MD

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Topics: asthma , drug usage

Prospective Study of Disease Persistence and Lung Function Trajectories of Childhood Asthma

Naiya B. Patel, MD; Christopher Parrish, MD

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Topics: asthma , asthma, childhood , pulmonary function , pulmonary function tests , respiratory physiology

Preparedness for Pediatric Office Emergencies: A Multicenter, Simulation-Based Study

Kelsey Lecerf, MD; David R. Stukus, MD

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Topics: disasters and emergency preparedness , emergency treatment , geographic population , outpatients , seizures

Airway Immune Mediator Levels During Asthma-Like Symptoms in Young Children and Their Possible Role in Response to Azithromycin

Stuart L. Abramson, MD, PhD

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Topics: airway device , airway structure , asthma , azithromycin , immune mediator

Stress Ulcer Prophylaxis for Critical Asthma

Jennifer S. Kim, MD

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Topics: asthma , stress ulcer , gastrointestinal bleeding

Safety of Live Attenuated Influenza Vaccine in Children With Asthma

Jennifer S. Kim, MD

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Topics: asthma, childhood , influenza vaccine, trivalent live attenuated , asthma , asthma, acute , geographic population

Physical Activity and Childhood Asthma Control: Mediation and Moderation Role of Body Mass Index

Abeer Siddiqi, MD; Joyce E. Yu, MD

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Topics: asthma, childhood , body mass index procedure , physical activity , asthma management , geographic population

Associations of Snoring and Asthma Morbidity in the School Inner-City Asthma Study

Paul Williams, MD

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Topics: asthma , snoring

Pediatric Sleep Questionnaire Predicts More Severe Sleep Apnea in Children With Uncontrolled Asthma

David Van, MD; Andrew Abreo, MD

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Topics: asthma , obstructive sleep apnea , sleep , sleep apnea syndromes , asthma management

Mental Well-Being and General Health in Adolescents With Asthma: The Prevention and Incidence of Asthma and Mite Allergy Birth Cohort Study

Gaytri Patel, MD; J. Andrew Bird, MD

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Topics: asthma , birth cohort , hypersensitivity , mites , personal satisfaction

Treatment

Treatment by Biomarker-informed Endotype Versus Guideline Care in Children With Difficult-to-treat Asthma

Rebecca M. Duron, MD; Jeffrey Chambliss, MD

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Topics: asthma , biological markers

Efficacy of Inhaled Salbutamol With and Without Prednisolone for First Acute Rhinovirus-induced Wheezing Episode

Mary V. Lasley, MD

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Topics: albuterol , prednisolone , rhinovirus , wheezing

Methylprednisolone, Dexamethasone, or Hydrocortisone for Acute Severe Pediatric Asthma: Does It Matter?

David Van, MD; Andrew Abreo, MD

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Topics: asthma, childhood , dexamethasone , hydrocortisone , methylprednisolone

Pragmatic Randomized Trial of Corticosteroids and Inhaled Epinephrine for Bronchiolitis in Children in Intensive Care

Cassie Shaw, MD; Elizabeth Wisner, MD

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Topics: adrenal corticosteroids , bronchiolitis , epinephrine , glucocorticoids , intensive care

Efficacy and Safety of As-Needed Budesonide-Formoterol in Adolescents With Mild Asthma

Ashley Lee, MD; Scott Sicherer, MD

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Topics: asthma , budesonide/formoterol

Adherence to Inhaled Corticosteroids Prescribed Once versus Twice Daily in Children With Asthma

Gilbert Ortega, MD; Jeffrey Chambliss, MD

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Topics: asthma, childhood , inhaled corticosteroid , geographic population

Triple versus Dual Inhaler Therapy and Asthma Outcomes in Moderate to Severe Asthma: A Systematic Review and Meta-analysis

Alan B Goldsobel, MD

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Topics: asthma , inhalers

Dupilumab in Children With Uncontrolled Moderate-to-Severe Asthma

Bradley E. Chipps, MD

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Topics: asthma , dupilumab

Efficacy and Safety of Itepekimab in Patients With Moderate-to-Severe Asthma

Bradley E. Chipps, MD

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Topics: asthma

Immunology

Clinical Features in a Large Cohort of Patients With 22q11.2 Deletion Syndrome

Jennifer M. Miller, MD; Lisa Forbes Satter, MD

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Topics: digeorge syndrome , signs and symptoms , recurrent infection , geographic population , t-lymphocytes

X-linked Agammaglobulinemia: Infection Frequency and Infection-Related Mortality in the USIDNET Registry

Kelli W. Williams, MD, MPH

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Topics: x-linked agammaglobulinemia , geographic population

Diagnostic Challenges in Pediatric Hemophagocytic Lymphohistiocytosis

Laurel G. Wolf, MD; Kelli W. Williams, MD, MPH

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Topics: hemophagocytic lymphohistiocytosis , hyperferritinemia , ferritin measurement , geographic population

Lower Airway Nitrogen Oxide Levels in Children With Primary Ciliary Dyskinesia is Linked to Neutrophilic Inflammation

Dexter Matrana, DO; Elizabeth Wisner, MD

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Topics: airway device , airway structure , arginine , ciliary motility disorders , cystic fibrosis

Treatment of Relapsing HPV Diseases by Restored Function of Natural Killer Cells

Samantha K. Knox, MD; Todd A. Mahr, MD

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Topics: human papillomavirus , natural killer cells , geographic population

Telemedicine for Children With Medical Complexity: A Randomized Clinical Trial

Kelsey Lecerf, MD; David R. Stukus, MD

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Topics: telemedicine , geographic population , medically complex conditions

Coronavirus Disease 2019 (Covid-19)

Assessment of Maternal and Neonatal Cord Blood SARS-CoV-2 Antibodies and Placental Transfer Ratios

Shouling Zhang, MD; Julie Wang, MD

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Topics: antibodies , newborn , placental transport , sars-cov-2 , umbilical cord blood

Clinical and Laboratory Characteristics of Children With SARS-CoV-2 Infection

Abeer Siddiqi, MD; Joyce E. Yu, MD

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Topics: covid-19 , sars-cov-2 , geographic population

Mild SARS-CoV-2 Infections and Neutralizing Antibody Titers

Kelsey Lecerf, MD; David R. Stukus, MD

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Topics: neutralizing antibodies , sars-cov-2 , covid-19

SARS-CoV-2−Reactive Mucosal B Cells in the Upper Respiratory Tract of Uninfected Individuals

Jessica Feng, MD; Christopher Parrish, MD

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Topics: b-lymphocytes , mucous membrane , severe acute respiratory syndrome , upper respiratory tract , sars-cov-2

Profound Dysregulation of T cell Homeostasis and Function in Patients With Severe COVID-19

Elinor Simons, MD, PhD

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Topics: covid-19 , homeostasis , t-lymphocytes

Parents’ Intentions and Perceptions About COVID-19 Vaccination for Their Children: Results From a National Survey

Erika Cherk, MD; Susan Laubach, MD

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Topics: covid-19 vaccines , perception

Association of COVID-19 Vaccination in Pregnancy With Adverse Peripartum Outcomes

Sarah Zimmerman, BA; Harvey L. Leo, MD

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Topics: covid-19 vaccines , vaccination , geographic population

Severity and Incidence of Multisystem Inflammatory Syndrome in Children During 3 SARS-CoV-2 Pandemic Waves in Israel

Sean Gallagher, MD; Harvey L. Leo, MD

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Topics: israel , pediatric inflammatory multisystem syndrome , wave - physical agent , coronavirus pandemic

Multisystem Inflammatory Syndrome in Children - Initial Therapy and Outcomes

Javier Cabrera-Pérez, MD, PhD; Michael Pistiner, MD, MMSc

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Topics: pediatric inflammatory multisystem syndrome , immunoglobulins, intravenous

Treatment of Multisystem Inflammatory Syndrome in Children

Samantha K. Knox, MD; Todd A. Mahr, MD

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Topics: pediatric inflammatory multisystem syndrome

Antibody Responses to the SARS-CoV-2 Vaccine in Individuals With Inborn Errors of Immunity

Mitchell R. Lester, MD

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Topics: antibody formation , covid-19 vaccines , immunity , immunoglobulin g , vaccines

Atypical Inflammatory Syndrome Triggered by SARS-CoV-2 in Infants With Down Syndrome

Adam Bartholomeo, MD, MS; Kelli W. Williams, MD, MPH

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Topics: atypical , down syndrome , pediatric inflammatory multisystem syndrome , sars-cov-2 , geographic population

Onset and Relapse of Juvenile Dermatomyositis Following Asymptomatic SARS-CoV-2 Infection

Adam Bartholomeo, MD, MS; Kelli W. Williams, MD, MPH

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Topics: covid-19 , juvenile dermatomyositis

Issues

Synopsis Book: Best Articles Relevant to Pediatric Allergy, Asthma and Immunology

Supplement Article

Allergy

Risk Factors and Prevention of Atopy

Anaphylaxis

Drug Allergy

Allergic Rhinitis

Allergic Skin Diseases

Food Allergy

IgE-Mediated Food Allergy

Non-IgE Mediated Food Allergy

Asthma

Epidemiology and Risk Factors

Diagnosis and Management

Treatment

Immunology

Coronavirus Disease 2019 (Covid-19)

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