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Immunogenicity of mRNA-1273 and BNT162b2 vaccines in children <5 years o...
Published: May 2024
FIGURE 1 Immunogenicity of mRNA-1273 and BNT162b2 vaccines in children <5 years of age. SARS-CoV-2-specific antibody binding and neutralization were compared by vaccine product (mRNA-1273 recipients: n = 40; BNT162b2 recipients: n = 35). A, The top heatmap displays the geometric means of SARS-CoV-2 variant-specific binding antibody responses as measured by BAMA by vaccine product. Antibody binding is expressed as mean fluorescence intensity (MFI) of serum antibodies specific to SARS-CoV-2 Spike proteins for each variant. The bottom heatmap displays the geometric means of variant-specific antibody neutralization titers (ID50) measured using a pseudovirus neutralization assay by vaccine product. B, Antibody binding of Spike proteins from D614G, Delta, and Omicron variants are expressed as mean fluorescence intensity (MFI) and shown by vaccine product. Each point represents data from an individual participant. The red line indicates the median, and the top and bottom of the box indicate the first and third quartiles. C, Antibody-mediated neutralization of D614G, Omicron BA.1, and Omicron BA.4/5 pseudoviruses, reported as ID50, for each vaccine product. Each point represents data from an individual participant. The red line indicates the median, and the top and bottom of the box indicate the first and third quartiles. No comparisons were significant by Wilcoxon rank-sum tests after correction for multiple testing. More about this image found in Immunogenicity of mRNA-1273 and BNT162b2 vaccines in children <5 years o...
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Immunogenicity of mRNA-1273 and BNT162b2 vaccines in children &lt;5 years o...
Published: May 2024
FIGURE 2 Immunogenicity of mRNA-1273 and BNT162b2 vaccines in children <5 years of age by history of before SARS-CoV-2 infection. SARS-CoV-2-specific antibody binding and neutralization activity were compared by vaccine product and previous SARS-CoV-2 infection history (mRNA-1273 recipients without previous infection: n = 28; mRNA-1273 recipients with previous infection: n = 12; BNT162b2 recipients without previous infection: n = 18; BNT162b2 recipients with previous infection: n = 17). A, The top heatmap displays the geometric means of SARS-CoV-2 variant-specific antibody by BAMA within each vaccine product by previous infection status. Antibody binding is expressed as mean fluorescence intensity of serum antibodies specific to SARS-CoV-2 Spike proteins for each variant. The bottom heatmap displays the geometric means of antibody neutralization titers (ID50) by vaccine product for each variant evaluated. B, Antibody binding of Spike proteins from D614G, Delta, and Omicron variants are expressed as mean fluorescence intensity (MFI) for each vaccine product by previous nfection status. Each point represents data from an individual participant. The red line indicates the median, and the top and bottom of the box indicate the first and third quartiles. C, Antibody-mediated neutralization of D614G, Omicron BA.1, and Omicron BA.4/5 pseudoviruses, reported as ID50, for each vaccine product by previous infection status. Each point represents data from an individual participant. The red line indicates the median, and the top and bottom of the box indicate the first and third quartiles. Statistical comparisons were made by using Wilcoxon rank-sum tests with P values adjusted for multiple comparisons (*Padj < .01; **Padj < .001; ***Padj < .0001). More about this image found in Immunogenicity of mRNA-1273 and BNT162b2 vaccines in children <5 years o...
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Immunogenicity of mRNA-1273 and BNT162b2 vaccines in young children by age ...
Published: May 2024
FIGURE 3 Immunogenicity of mRNA-1273 and BNT162b2 vaccines in young children by age category. SARS-CoV-2-specific antibody binding and neutralization were compared by vaccine product and age category (mRNA-1273 recipients 6-23 months of age: n = 18; mRNA-1273 recipients 24–59 months of age: n = 22; BNT162b2 recipients 6–23 months of age: n = 17; BNT162b2 recipients 24–59 months of age: n = 18). A, The top heatmap displays the geometric means of SARS-CoV-2 variant-specific antibody by BAMA within each vaccine product by age category. Antibody binding is expressed as mean fluorescence intensity (MFI) of serum antibodies specific to SARS-CoV-2 Spike proteins for each variant. The bottom heatmap displays the geometric means of antibody neutralization titers (ID50) by vaccine product for each variant evaluated. B, Antibody binding of Spike proteins from D614G, Delta, and Omicron variants are expressed as mean fluorescence intensity (MFI) for each vaccine product by age category. Each point represents data from an individual participant. The red line indicates the median, and the top and bottom of the box indicate the first and third quartiles. C, Antibody-mediated neutralization of D614G, Omicron BA.1, and Omicron BA.4/5 pseudoviruses, reported as ID50, for each vaccine product by age category. Each point represents data from an individual participant. The red line indicates the median, and the top and bottom of the box indicate the first and third quartiles. No comparisons were significant by Wilcoxon rank-sum tests after correction for multiple testing. More about this image found in Immunogenicity of mRNA-1273 and BNT162b2 vaccines in young children by age ...
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Average predicted probabilities of GD diagnosis (PEDSnet) and transgender i...
Published: May 2024
FIGURE 1 Average predicted probabilities of GD diagnosis (PEDSnet) and transgender identity (YRBS) by demographic characteristics. a Sex is the EMR-reported sex for the PEDSnet data set. PEDSnet analyses were adjusted for age in years on the data extraction date, EMR-reported sex, and race and ethnicity, and modeled institution as a random effect to account for clustering at the health system level. YRBS analyses were adjusted for age in years, sex, and race and ethnicity, and used sampling weights and adjusted variance estimates to account for survey design. More about this image found in Average predicted probabilities of GD diagnosis (PEDSnet) and transgender i...
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RI-CLPM of confirmed child maltreatment and externalizing behaviors. All es...
Published: May 2024
FIGURE 1 RI-CLPM of confirmed child maltreatment and externalizing behaviors. All estimates are unstandardized. Where behavior problems were the outcome, path coefficients are reported as unstandardized estimates interpreted as the change in T-scores (M = 50; SD = 10) when a given individual experienced confirmed child maltreatment. Dashed lines are nonsignificant paths. Bolded lines are significant cross-lagged paths. Fit statistics: χ283 = 179.76, P < .001; CFI 0.97; RMSEA 0.03, (95% CI 0.02–0.04). P < .05 was considered statistically significant. CM, confirmed child maltreatment; EXT, externalizing behavior problems. aP ≤ .05; bP ≤ .01; cP ≤ .001. More about this image found in RI-CLPM of confirmed child maltreatment and externalizing behaviors. All es...
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RI-CLPM of confirmed child maltreatment and internalizing behaviors. All es...
Published: May 2024
FIGURE 2 RI-CLPM of confirmed child maltreatment and internalizing behaviors. All estimates are unstandardized. Where behavior problems were the outcome, path coefficients are reported as unstandardized estimates interpreted as the change in T-scores (M = 50; SD = 10) when a given individual experienced confirmed child maltreatment. Dashed lines are nonsignificant paths. Bolded lines are significant cross-lagged paths. Fit statistics: χ283 = 235.40, P < .001; CFI 0.93; RMSEA 0.04, (95% CI 0.03–0.04). P < .05 was considered statistically significant. CM, confirmed child maltreatment; INT, internalizing behavior problems. aP ≤ .05; bP ≤ .01; cP ≤ .001. More about this image found in RI-CLPM of confirmed child maltreatment and internalizing behaviors. All es...