A reader raised two questions regarding the article on migraine in children (Pediatrics in Review. 1994; 15:94-101):

1. Is low dosage aspirin effective prophylaxis for migraine?

2. What is the role of platelets in the pathogenesis of migraine?

Dr. Singer responds:

Aspirin does, indeed, provide relief for many of those who have migraines. Its overuse, however, can have serious side effects. Further, some are hesitant to use it based on established reports of headaches induced by chronic aspirin treatment and its potential role as a factor in Reye syndrome. Although the value of aspirin in headache syndromes may be related, in part, to its effect on platelets, it also is a well-established analgesic medication.

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