Adenoviruses are DNA viruses that are important etiologic agents of respiratory tract infections, conjunctivitis, gastroenteritis,and fever in children. Forty-nine adenovirus serotypes are known to infect humans. Particular serotypes tend to infect specific sites and organs. Most children are infected by adenovirus at an early age. By 5 years of age, 70% to 80% of children demonstrate antibodies to at least one serotype. Adenoviral infections occur sporadically throughout the year, but epidemics have been associated with child care centers,hospitals, physicians’ offices, college students, and military recruits in basic training.

Adenoviruses cause approximately 10% of all respiratory infections in children, with serotypes 1, 2, 3, and 5 being the most common respiratory pathogens. The incidence increases slightly in the late winter, spring, and early summer months. Transmission occurs via aerosolized droplets, with the incubation period ranging from 2 to 14 days. The most commonly seen respiratory syndromes include the common cold and...

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