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Asthma, allergic rhinitis, and atopic dermatitis are multifactorial diseases that are linked by a complex combination of hereditary and environmental factors. The terms atopy and atopic were introduced by Coca in l923, who concluded that because no antibody could be detected in vitro in allergic disorders, these conditions should be called “atopy,”meaning “a strange disease”. In collaboration with Cooke, he suggested that “atopic” be used to describe patients who experienced seasonal allergic rhinitis or asthma as well as other forms of allergy in which “the individuals as a group possess a peculiar capacity to become sensitive to certain proteins in which their environment and habits of life expose them.“ Since this initial description more than 70 years ago,multiple factors have been identified that predispose to the risk of allergic diseases. Abnormal sensitivity(atopy) is mediated by immunoglobulin E (IgE) and has a...

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