In 2000, the United States Food and Drug Administration(FDA) approved 160 medications and medical devices, many that have pediatric indications. We discuss eight of these medications that have clinical importance to the general pediatrician. Two of the medications are new drugs (Table 1), three represent new delivery systems for existing drugs (Table 2), and three are new combinations of drugs (Table 3).

Lantus (insulin glargine, Aventis, Parsippany, NJ) is a long-acting recombinant human insulin analog indicated for the management of insulin-dependent diabetes mellitus. It has a relatively constant glucose-lowering profile without peaks and valleys over 24 hours, allowing it to be administered once every 24 hours. It may be best suited as a substitute for patients receiving twice-daily intermediate-acting insulin, for those experiencing the“dawn phenomenon” with an intermediate-acting insulin, or for those who experience hypoglycemia from intermediate- or long-acting insulins. It is approved for use in children 6...

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