Clinicians must learn to recognize the spectrum of clinical syndromes associated with enteroviruses. Examples include the association of asthma exacerbation with enterovirus D68 and the association of acute eczema flare-up with coxsackievirus A16.

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During Monday morning clinic in mid-July, you refer 2 cases to the emergency department (ED). The first is a 2-week-old neonate who has had 1 day of decreased oral intake and a temperature of 102°F (38.9°C) at your clinic. The baby appears alert with normal findings on physical examination. Later in the morning you receive an update call from the ED attending physician. Examination of the cerebrospinal fluid (CSF) shows pleocytosis with 55 white blood cells/μL but normal glucose (68 mg/dL) and protein (90 mg/dL) measurements. The Gram stain is negative. The CSF is positive for enterovirus (EV) by polymerase chain reaction (PCR) assay.

The second case is...

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