A baby boy with concern for ventriculomegaly on prenatal ultrasonography is born at term by urgent cesarean delivery for fetal intolerance of labor. The mother received regular prenatal care. Maternal serologic test results were normal. She denied any travel, trauma, or illness during the pregnancy. Apgar scores were 8 and 9 at 1 and 5 minutes, respectively.

On initial examination the boy appears nondysmorphic and proportionately small, being less than the 10th percentile for weight, length, and head circumference. Neurologic examination is notable for poorly coordinated suck and nonhabituation to light and glabellar tap. The eyes are not adequately visualized secondary to periorbital edema initially; however, follow-up ophthalmologic evaluation demonstrates bilateral cataracts. The remainder of the physical examination findings are normal.

A brain magnetic resonance image is obtained to better characterize the brain abnormalities noted on ultrasonography. Large porencephalic cysts, absent corpus collosum, absent septum pellucidum, and abnormal neuronal migration...

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