Coronavirus disease 2019 (COVID-19) has become an integral part of clinical care in both primary care and hospital-based care settings. Information related to COVID-19 has accumulated rapidly in the first 2 years of the pandemic (2020–2022), and pediatric providers should keep up with recent updates on the condition. In particular, pediatric providers should be familiar with the epidemiology and transmission of severe acute respiratory syndrome coronavirus 2, the virus that causes COVID-19, as well as the clinical manifestations of COVID-19, including acute COVID-19, multisystem inflammatory syndrome in children, and post-acute COVID-19 syndrome; management, including antiviral and anti-inflammatory therapies; and preventive measures, including immunization and transmission reduction measures.

After completing this article, readers should be able to:

  1. Describe clinical manifestations of pediatric coronavirus disease 2019 (COVID-19), including acute COVID-19, multisystem inflammatory syndrome in children, and post-acute COVID-19 syndrome.

  2. Discuss management of COVID-19, including antiviral and anti-inflammatory therapeutics in children.

  3. Discuss preventive...

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