Herpes Simplex

In newborn infants, herpes simplex virus (HSV) infection can manifest as: (1) disseminated disease involving multiple organs, most prominently liver and lungs, and in 60% to 75% of cases also involving the central nervous system (CNS); (2) localized CNS disease, with or without skin, eye, or mouth involvement (CNS disease); or (3) disease localized to the skin, eyes, and/or mouth (SEM disease). Approximately 25% of cases of neonatal HSV manifest as disseminated disease, 30% manifest as CNS disease, and 45% manifest as SEM disease. Both HSV type 1 (HSV-1) and type 2 (HSV-2) can cause any of these...