Syphilis

Intrauterine infection with Treponema pallidum can result in stillbirth, hydrops fetalis, or preterm birth or may be asymptomatic at birth. Infected infants can have hepatosplenomegaly; snuffles (copious nasal secretions); lymphadenopathy; mucocutaneous lesions; pneumonia; osteochondritis, periostitis, and pseudoparalysis; edema; rash (maculopapular consisting of small dark red-copper spots that is most severe on the hands and feet); hemolytic anemia; or thrombocytopenia at birth or within the first 4 to 8 weeks of age. Untreated infants, including those asymptomatic at birth, may develop late manifestations, which usually appear after 2 years of age and involve the central nervous...