| . | <1 Years (n = 176) . | 1–4 Years (n = 122) . | 5–11 Years (n = 143) . | 12–17 Years (n = 272) . | 18–20 Years (n = 46) . |
|---|---|---|---|---|---|
| WBC, 109/L | |||||
| Admission, n | 54 | 54 | 73 | 145 | 31 |
| Median (IQR) | 9.8 (6.3–13.0) | 8.1 (5.5–13.9) | 5.8 (4.3–8.5) | 5.3 (3.9–7.5) | 5.6 (4.5–8.1) |
| Peak, n | 62 | 54 | 72 | 147 | 33 |
| Median (IQR) | 10.7 (6.6–13.4) | 9.8 (6.0–13.9) | 6.8 (4.9–9.8) | 7.1 (4.8–10.5) | 7.2 (4.8–11.3) |
| Nadir, n | 62 | 54 | 73 | 147 | 33 |
| Median (IQR) | 8.1 (5.7–12.1) | 6.9 (4.7–12.0) | 4.9 (3.5–7.4) | 4.8 (3.6–6.8) | 4.6 (4.3–7.0) |
| Hemoglobin, g/dL | |||||
| Admission, n | 36 | 31 | 39 | 96 | 27 |
| Median (IQR) | 11.0 (9.8–12.8) | 11.4 (9.7–12.5) | 12.4 (11.3–13.6) | 13.2 (11.8–14.8) | 13.3 (12.2–15.0) |
| Nadir, n | 29 | 24 | 35 | 91 | 27 |
| Median (IQR) | 10.8 (8.8–11.9) | 10.8 (9.4–12.3) | 12.3 (10.9–13.9) | 12.6 (10.3–14.1) | 12.2 (10.9–13.8) |
| Platelets, cells/mm3 | |||||
| Admission, n | 65 | 54 | 74 | 149 | 32 |
| Median (IQR) | 362 (263–451) | 273 (183–355) | 231 (146–306) | 211 (157–275) | 189 (161–260) |
| Peak, n | 64 | 53 | 73 | 151 | 34 |
| Median (IQR) | 370 (280–470) | 296 (234–367) | 270 (191–359) | 264 (197–350) | 258 (191–331) |
| Nadir, n | 63 | 53 | 74 | 151 | 34 |
| Median (IQR) | 333 (249–412) | 239 (149–314) | 208 (144–270) | 195 (143–242) | 177 (132–227) |
| D-dimer, mg FEU/L | |||||
| Admission, n | 12 | 19 | 49 | 166 | 18 |
| Median (IQR) | 0.9 (0.7–1.3) | 0.7 (0.5–1.3) | 0.9 (0.5–1.7) | 1.0 (0.6–1.6) | 0.9 (0.6–1.6) |
| Peak, n | 13 | 22 | 58 | 173 | 23 |
| Median (IQR) | 0.9 (0.9–1.1) | 0.7 (0.5–1.5) | 1.0 (0.5–2.0) | 1.0 (0.6–1.9) | 1.0 (0.6–2.8) |
| Creatinine, mg/dL | |||||
| Admission, n | 73 | 68 | 99 | 209 | 32 |
| Median (IQR) | 0.3 (0.2–0.3) | 0.3 (0.2–0.4) | 0.5 (0.3–0.5) | 0.7 (0.5–0.8) | 0.7 (0.5–0.9) |
| Peak, n | 75 | 67 | 99 | 213 | 36 |
| Median (IQR) | 0.3 (0.2–0.3) | 0.3 (0.2–0.4) | 0.5 (0.4–0.6) | 0.7 (0.6–0.9) | 0.8 (0.5–1.0) |
| AST, U/L | |||||
| Peak, n | 66 | 51 | 90 | 187 | 34 |
| Median (IQR) | 47 (31–70) | 57 (41–89) | 62 (34–92) | 59 (35–107) | 77 (43–121) |
| ALT, U/L | |||||
| Peak, n | 66 | 51 | 90 | 187 | 34 |
| Median (IQR) | 23 (17–34) | 27 (17–40) | 31 (16–71) | 40 (22–100) | 57 (29–141) |
| CRP, mg/L | |||||
| Admission, n | 40 | 39 | 69 | 162 | 23 |
| Median (IQR) | 11.0 (5.0–41.0) | 26.0 (6.0–88.0) | 15.0 (7.0–45.0) | 36.5 (14.0–72.0) | 54.0 (24.0–70.0) |
| Peak, n | 43 | 39 | 74 | 172 | 28 |
| Median (IQR) | 14.0 (5.0–45.0) | 30.0 (8.0–88.0) | 20.5 (9.0–56.0) | 42.5 (14.0–82.5) | 61.0 (39.5–102) |
| Procalcitonin, ng/mL | |||||
| Admission, n | 48 | 33 | 55 | 131 | 17 |
| Median (IQR) | 0.2 (0.1–0.4) | 1.1 (0.2–7.1) | 0.1 (0.1–0.4) | 0.2 (0.1–0.4) | 0.1 (0.1–0.2) |
| Peak, n | 49 | 32 | 62 | 141 | 19 |
| Median (IQR) | 0.2 (0.1–0.3) | 1.1 (0.2–6.5) | 0.1 (0.1–0.4) | 0.2 (0.1–0.4) | 0.1 (0.1–0.2) |
| Ferritin, ng/mL | |||||
| Admission, n | 13 | 22 | 45 | 122 | 13 |
| Median (IQR) | 140 (75–253) | 94 (62–201) | 156 (92–300) | 243 (126–447) | 305 (205–580) |
| Peak, n | 16 | 25 | 52 | 132 | 17 |
| Median (IQR) | 175 (83–486) | 99 (67–207) | 192 (101, 377) | 243 (128–559) | 305 (109–629) |
| . | <1 Years (n = 176) . | 1–4 Years (n = 122) . | 5–11 Years (n = 143) . | 12–17 Years (n = 272) . | 18–20 Years (n = 46) . |
|---|---|---|---|---|---|
| WBC, 109/L | |||||
| Admission, n | 54 | 54 | 73 | 145 | 31 |
| Median (IQR) | 9.8 (6.3–13.0) | 8.1 (5.5–13.9) | 5.8 (4.3–8.5) | 5.3 (3.9–7.5) | 5.6 (4.5–8.1) |
| Peak, n | 62 | 54 | 72 | 147 | 33 |
| Median (IQR) | 10.7 (6.6–13.4) | 9.8 (6.0–13.9) | 6.8 (4.9–9.8) | 7.1 (4.8–10.5) | 7.2 (4.8–11.3) |
| Nadir, n | 62 | 54 | 73 | 147 | 33 |
| Median (IQR) | 8.1 (5.7–12.1) | 6.9 (4.7–12.0) | 4.9 (3.5–7.4) | 4.8 (3.6–6.8) | 4.6 (4.3–7.0) |
| Hemoglobin, g/dL | |||||
| Admission, n | 36 | 31 | 39 | 96 | 27 |
| Median (IQR) | 11.0 (9.8–12.8) | 11.4 (9.7–12.5) | 12.4 (11.3–13.6) | 13.2 (11.8–14.8) | 13.3 (12.2–15.0) |
| Nadir, n | 29 | 24 | 35 | 91 | 27 |
| Median (IQR) | 10.8 (8.8–11.9) | 10.8 (9.4–12.3) | 12.3 (10.9–13.9) | 12.6 (10.3–14.1) | 12.2 (10.9–13.8) |
| Platelets, cells/mm3 | |||||
| Admission, n | 65 | 54 | 74 | 149 | 32 |
| Median (IQR) | 362 (263–451) | 273 (183–355) | 231 (146–306) | 211 (157–275) | 189 (161–260) |
| Peak, n | 64 | 53 | 73 | 151 | 34 |
| Median (IQR) | 370 (280–470) | 296 (234–367) | 270 (191–359) | 264 (197–350) | 258 (191–331) |
| Nadir, n | 63 | 53 | 74 | 151 | 34 |
| Median (IQR) | 333 (249–412) | 239 (149–314) | 208 (144–270) | 195 (143–242) | 177 (132–227) |
| D-dimer, mg FEU/L | |||||
| Admission, n | 12 | 19 | 49 | 166 | 18 |
| Median (IQR) | 0.9 (0.7–1.3) | 0.7 (0.5–1.3) | 0.9 (0.5–1.7) | 1.0 (0.6–1.6) | 0.9 (0.6–1.6) |
| Peak, n | 13 | 22 | 58 | 173 | 23 |
| Median (IQR) | 0.9 (0.9–1.1) | 0.7 (0.5–1.5) | 1.0 (0.5–2.0) | 1.0 (0.6–1.9) | 1.0 (0.6–2.8) |
| Creatinine, mg/dL | |||||
| Admission, n | 73 | 68 | 99 | 209 | 32 |
| Median (IQR) | 0.3 (0.2–0.3) | 0.3 (0.2–0.4) | 0.5 (0.3–0.5) | 0.7 (0.5–0.8) | 0.7 (0.5–0.9) |
| Peak, n | 75 | 67 | 99 | 213 | 36 |
| Median (IQR) | 0.3 (0.2–0.3) | 0.3 (0.2–0.4) | 0.5 (0.4–0.6) | 0.7 (0.6–0.9) | 0.8 (0.5–1.0) |
| AST, U/L | |||||
| Peak, n | 66 | 51 | 90 | 187 | 34 |
| Median (IQR) | 47 (31–70) | 57 (41–89) | 62 (34–92) | 59 (35–107) | 77 (43–121) |
| ALT, U/L | |||||
| Peak, n | 66 | 51 | 90 | 187 | 34 |
| Median (IQR) | 23 (17–34) | 27 (17–40) | 31 (16–71) | 40 (22–100) | 57 (29–141) |
| CRP, mg/L | |||||
| Admission, n | 40 | 39 | 69 | 162 | 23 |
| Median (IQR) | 11.0 (5.0–41.0) | 26.0 (6.0–88.0) | 15.0 (7.0–45.0) | 36.5 (14.0–72.0) | 54.0 (24.0–70.0) |
| Peak, n | 43 | 39 | 74 | 172 | 28 |
| Median (IQR) | 14.0 (5.0–45.0) | 30.0 (8.0–88.0) | 20.5 (9.0–56.0) | 42.5 (14.0–82.5) | 61.0 (39.5–102) |
| Procalcitonin, ng/mL | |||||
| Admission, n | 48 | 33 | 55 | 131 | 17 |
| Median (IQR) | 0.2 (0.1–0.4) | 1.1 (0.2–7.1) | 0.1 (0.1–0.4) | 0.2 (0.1–0.4) | 0.1 (0.1–0.2) |
| Peak, n | 49 | 32 | 62 | 141 | 19 |
| Median (IQR) | 0.2 (0.1–0.3) | 1.1 (0.2–6.5) | 0.1 (0.1–0.4) | 0.2 (0.1–0.4) | 0.1 (0.1–0.2) |
| Ferritin, ng/mL | |||||
| Admission, n | 13 | 22 | 45 | 122 | 13 |
| Median (IQR) | 140 (75–253) | 94 (62–201) | 156 (92–300) | 243 (126–447) | 305 (205–580) |
| Peak, n | 16 | 25 | 52 | 132 | 17 |
| Median (IQR) | 175 (83–486) | 99 (67–207) | 192 (101, 377) | 243 (128–559) | 305 (109–629) |
ALT, alanine aminotransferase; AST, aspartate aminotransferase; CRP, C-reactive protein; WBC, white blood cells.
a Normal age- and sex-specific values were referenced from the Harriet Lane Handbook.25 Laboratory measurements > or < than a value of detection were designated as equal to those values.
b Laboratory data were not available from Children’s National Hospital, Washington, DC.