Risk Factors for Developing Significant Hyperbilirubinemia
| Risk Factors . |
|---|
| • Lower gestational age (ie, risk increases with each additional week less than 40 wk) |
| • Jaundice in the first 24 h after birth |
| • Predischarge transcutaneous bilirubin (TcB) or total serum bilirubin (TSB) concentration close to the phototherapy threshold |
| • Hemolysis from any cause, if known or suspected based on a rapid rate of increase in the TSB or TcB of >0.3 mg/dL per hour in the first 24 h or >0.2 mg/dL per hour thereafter. |
| • Phototherapy before discharge |
| • Parent or sibling requiring phototherapy or exchange transfusion |
| • Family history or genetic ancestry suggestive of inherited red blood cell disorders, including glucose-6-phosphate dehydrogenase (G6PD) deficiency |
| • Exclusive breastfeeding with suboptimal intake |
| • Scalp hematoma or significant bruising |
| • Down syndrome |
| • Macrosomic infant of a diabetic mother |
| Risk Factors . |
|---|
| • Lower gestational age (ie, risk increases with each additional week less than 40 wk) |
| • Jaundice in the first 24 h after birth |
| • Predischarge transcutaneous bilirubin (TcB) or total serum bilirubin (TSB) concentration close to the phototherapy threshold |
| • Hemolysis from any cause, if known or suspected based on a rapid rate of increase in the TSB or TcB of >0.3 mg/dL per hour in the first 24 h or >0.2 mg/dL per hour thereafter. |
| • Phototherapy before discharge |
| • Parent or sibling requiring phototherapy or exchange transfusion |
| • Family history or genetic ancestry suggestive of inherited red blood cell disorders, including glucose-6-phosphate dehydrogenase (G6PD) deficiency |
| • Exclusive breastfeeding with suboptimal intake |
| • Scalp hematoma or significant bruising |
| • Down syndrome |
| • Macrosomic infant of a diabetic mother |