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TABLE 1

Risk Factors for Developing Significant Hyperbilirubinemia

Risk Factors
• Lower gestational age (ie, risk increases with each additional week less than 40 wk) 
• Jaundice in the first 24 h after birth 
• Predischarge transcutaneous bilirubin (TcB) or total serum bilirubin (TSB) concentration close to the phototherapy threshold 
• Hemolysis from any cause, if known or suspected based on a rapid rate of increase in the TSB or TcB of >0.3 mg/dL per hour in the first 24 h or >0.2 mg/dL per hour thereafter. 
• Phototherapy before discharge 
• Parent or sibling requiring phototherapy or exchange transfusion 
• Family history or genetic ancestry suggestive of inherited red blood cell disorders, including glucose-6-phosphate dehydrogenase (G6PD) deficiency 
• Exclusive breastfeeding with suboptimal intake 
• Scalp hematoma or significant bruising 
• Down syndrome 
• Macrosomic infant of a diabetic mother 
Risk Factors
• Lower gestational age (ie, risk increases with each additional week less than 40 wk) 
• Jaundice in the first 24 h after birth 
• Predischarge transcutaneous bilirubin (TcB) or total serum bilirubin (TSB) concentration close to the phototherapy threshold 
• Hemolysis from any cause, if known or suspected based on a rapid rate of increase in the TSB or TcB of >0.3 mg/dL per hour in the first 24 h or >0.2 mg/dL per hour thereafter. 
• Phototherapy before discharge 
• Parent or sibling requiring phototherapy or exchange transfusion 
• Family history or genetic ancestry suggestive of inherited red blood cell disorders, including glucose-6-phosphate dehydrogenase (G6PD) deficiency 
• Exclusive breastfeeding with suboptimal intake 
• Scalp hematoma or significant bruising 
• Down syndrome 
• Macrosomic infant of a diabetic mother 
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