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TABLE 2

Hyperbilirubinemia Neurotoxicity Risk Factors

Risk Factors
• Gestational age <38 wk and this risk increases with the degree of prematuritya 
• Albumin <3.0 g/dL 
• Isoimmune hemolytic disease (ie, positive direct antiglobulin test), G6PD deficiency, or other hemolytic conditions 
• Sepsis 
• Significant clinical instability in the previous 24 h 
Risk Factors
• Gestational age <38 wk and this risk increases with the degree of prematuritya 
• Albumin <3.0 g/dL 
• Isoimmune hemolytic disease (ie, positive direct antiglobulin test), G6PD deficiency, or other hemolytic conditions 
• Sepsis 
• Significant clinical instability in the previous 24 h 

aGestational age is required to identify the phototherapy thresholds (Figs 2 and 3; Supplemental Tables 1 and 2, and Supplemental Figs 1 and 2) and the exchange transfusion thresholds (Figs 5 and 6; Supplemental Tables 3 and 4, and Supplemental Figs 3 and 4).

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