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TABLE 2

Results of Cox Proportional Models Evaluating Associations Between Participant Characteristics and Each Event of Interest

Independent VariablesCrude HR95% CIAdjusted HR95% CI
Outcome: GDRD     
 Assigned sex at birth     
  Male (AMAB) 1.0 Reference 1.0 Reference 
  Female (AFAB) 1.5 1.2–1.9 1.3 1.0–1.7 
 Race and/or ethnicity     
  Non-Hispanic white children 1.0 Reference 1.0 Reference 
  Other groups 0.8 0.6–1.0 0.8 0.6–1.0 
 Age at index date, y     
  3–9 1.0 Reference 1.0 Reference 
  10–14 2.0 1.3–3.0 2.0 1.3–3.0 
  ≥15 2.8 1.9–4.1 2.7 1.8–3.9 
 Study site     
  Georgia 1.0 Reference 1.0 Reference 
  Northern California 1.0 0.8–1.2 1.0 0.8–1.3 
  Southern California 0.5 0.2–1.3 0.5 0.2–1.3 
Outcome: GAHT initiationa     
 Recorded sex at birth     
  Male (AMAB) 1.0 Reference 1.0 Reference 
  Female (AFAB) 3.0 2.2–4.0 2.5 1.8–3.3 
 Race and ethnicity     
  Non-Hispanic white children 1.0 Reference 1.0 Reference 
  Other groupsb 0.6 0.5–0.8 0.6 0.5–0.8 
Independent VariablesCrude HR95% CIAdjusted HR95% CI
Outcome: GDRD     
 Assigned sex at birth     
  Male (AMAB) 1.0 Reference 1.0 Reference 
  Female (AFAB) 1.5 1.2–1.9 1.3 1.0–1.7 
 Race and/or ethnicity     
  Non-Hispanic white children 1.0 Reference 1.0 Reference 
  Other groups 0.8 0.6–1.0 0.8 0.6–1.0 
 Age at index date, y     
  3–9 1.0 Reference 1.0 Reference 
  10–14 2.0 1.3–3.0 2.0 1.3–3.0 
  ≥15 2.8 1.9–4.1 2.7 1.8–3.9 
 Study site     
  Georgia 1.0 Reference 1.0 Reference 
  Northern California 1.0 0.8–1.2 1.0 0.8–1.3 
  Southern California 0.5 0.2–1.3 0.5 0.2–1.3 
Outcome: GAHT initiationa     
 Recorded sex at birth     
  Male (AMAB) 1.0 Reference 1.0 Reference 
  Female (AFAB) 3.0 2.2–4.0 2.5 1.8–3.3 
 Race and ethnicity     
  Non-Hispanic white children 1.0 Reference 1.0 Reference 
  Other groupsb 0.6 0.5–0.8 0.6 0.5–0.8 
a

Model was stratified on age and study site because of violation of proportional hazards assumption for these 2 variables; for this reason, the results are controlled for age and study site, but no HR estimates are provided.

b

Includes persons with unknown race and ethnicity.

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