Results of Cox Proportional Models Evaluating Associations Between Participant Characteristics and Each Event of Interest
| Independent Variables . | Crude HR . | 95% CI . | Adjusted HR . | 95% CI . |
|---|---|---|---|---|
| Outcome: GDRD | ||||
| Assigned sex at birth | ||||
| Male (AMAB) | 1.0 | Reference | 1.0 | Reference |
| Female (AFAB) | 1.5 | 1.2–1.9 | 1.3 | 1.0–1.7 |
| Race and/or ethnicity | ||||
| Non-Hispanic white children | 1.0 | Reference | 1.0 | Reference |
| Other groups | 0.8 | 0.6–1.0 | 0.8 | 0.6–1.0 |
| Age at index date, y | ||||
| 3–9 | 1.0 | Reference | 1.0 | Reference |
| 10–14 | 2.0 | 1.3–3.0 | 2.0 | 1.3–3.0 |
| ≥15 | 2.8 | 1.9–4.1 | 2.7 | 1.8–3.9 |
| Study site | ||||
| Georgia | 1.0 | Reference | 1.0 | Reference |
| Northern California | 1.0 | 0.8–1.2 | 1.0 | 0.8–1.3 |
| Southern California | 0.5 | 0.2–1.3 | 0.5 | 0.2–1.3 |
| Outcome: GAHT initiationa | ||||
| Recorded sex at birth | ||||
| Male (AMAB) | 1.0 | Reference | 1.0 | Reference |
| Female (AFAB) | 3.0 | 2.2–4.0 | 2.5 | 1.8–3.3 |
| Race and ethnicity | ||||
| Non-Hispanic white children | 1.0 | Reference | 1.0 | Reference |
| Other groupsb | 0.6 | 0.5–0.8 | 0.6 | 0.5–0.8 |
| Independent Variables . | Crude HR . | 95% CI . | Adjusted HR . | 95% CI . |
|---|---|---|---|---|
| Outcome: GDRD | ||||
| Assigned sex at birth | ||||
| Male (AMAB) | 1.0 | Reference | 1.0 | Reference |
| Female (AFAB) | 1.5 | 1.2–1.9 | 1.3 | 1.0–1.7 |
| Race and/or ethnicity | ||||
| Non-Hispanic white children | 1.0 | Reference | 1.0 | Reference |
| Other groups | 0.8 | 0.6–1.0 | 0.8 | 0.6–1.0 |
| Age at index date, y | ||||
| 3–9 | 1.0 | Reference | 1.0 | Reference |
| 10–14 | 2.0 | 1.3–3.0 | 2.0 | 1.3–3.0 |
| ≥15 | 2.8 | 1.9–4.1 | 2.7 | 1.8–3.9 |
| Study site | ||||
| Georgia | 1.0 | Reference | 1.0 | Reference |
| Northern California | 1.0 | 0.8–1.2 | 1.0 | 0.8–1.3 |
| Southern California | 0.5 | 0.2–1.3 | 0.5 | 0.2–1.3 |
| Outcome: GAHT initiationa | ||||
| Recorded sex at birth | ||||
| Male (AMAB) | 1.0 | Reference | 1.0 | Reference |
| Female (AFAB) | 3.0 | 2.2–4.0 | 2.5 | 1.8–3.3 |
| Race and ethnicity | ||||
| Non-Hispanic white children | 1.0 | Reference | 1.0 | Reference |
| Other groupsb | 0.6 | 0.5–0.8 | 0.6 | 0.5–0.8 |
Model was stratified on age and study site because of violation of proportional hazards assumption for these 2 variables; for this reason, the results are controlled for age and study site, but no HR estimates are provided.
Includes persons with unknown race and ethnicity.