American Academy of Pediatrics

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TABLE 3

Number of Immunogenic Proteins and Polysaccharides Contained in Vaccines Over the Past 100 Years

1890		1960		1980		2000
Vaccine	Proteins	Vaccine	Proteins	Vaccine	Proteins	Vaccine	Proteins and Polysaccharides
Smallpox	∼200	Smallpox	∼200	Diphtheria	1	Diphtheria	1
Total	∼200	Diphtheria	1	Tetanus	1	Tetanus	1
		Tetanus	1	WC-pertussis	∼3000	AC-pertussis	2–5
		WC-pertussis	∼3000	Polio	15	Polio	15
		Polio	15	Measles	10	Measles	10
		Total	∼3217	Mumps	9	Mumps	9
				Rubella	5	Rubella	5
				Total	̴3041	Hib	2
						Varicella	69
						Pneumococcus	8
						Hepatitis B	1
						Total	123–126

1890		1960		1980		2000
Vaccine	Proteins	Vaccine	Proteins	Vaccine	Proteins	Vaccine	Proteins and Polysaccharides
Smallpox	∼200	Smallpox	∼200	Diphtheria	1	Diphtheria	1
Total	∼200	Diphtheria	1	Tetanus	1	Tetanus	1
		Tetanus	1	WC-pertussis	∼3000	AC-pertussis	2–5
		WC-pertussis	∼3000	Polio	15	Polio	15
		Polio	15	Measles	10	Measles	10
		Total	∼3217	Mumps	9	Mumps	9
				Rubella	5	Rubella	5
				Total	̴3041	Hib	2
						Varicella	69
						Pneumococcus	8
						Hepatitis B	1
						Total	123–126

Adapted from Offit et al.⁵²

AC-pertussis, acellular pertussis vaccine; WC-pertussis, whole cell pertussis vaccine.