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TABLE 4

High-Risk Groups for Influenza Complications

CategoryDescription
Demographic characteristics Children <5 y, especially those <2 ya 
 Residents of a chronic care facility or nursing home 
Underlying condition or treatment with common examplesb 
 Chronic pulmonary disease Asthma 
 Cystic fibrosis 
 Compromised respiratory function (eg, requiring mechanical ventilation, tracheostomy) 
 Cardiovascular disease Hemodynamically significant conditions (excluding hypertension alone) 
 Kidney disease Chronic kidney disease, including end-stage kidney disease 
 Dialysis 
 Hepatic disease Chronic liver disease 
 Cirrhosis11,12  
 Hematologic disease Sickle cell disease 
 Other hemoglobinopathies 
 Metabolic disorders Diabetes mellitus 
 Neurologic and neurodevelopmental conditions Cerebral palsy 
Epilepsy 
 Stroke 
 Intellectual developmental disorder 
 Moderate to severe developmental delay 
 Muscular dystrophy 
 Spinal cord injury 
 Extreme obesity BMI ≥40 for adultsc 
 Immunosuppression Receipt of immuncompromising medications 
 Congenital or acquired immune deficiency, including HIV 
 Asplenia 
Receiving treatment with aspirin or salicylate-containing therapiesd 
Pregnancy and up to 2 wk’ postpartum 
CategoryDescription
Demographic characteristics Children <5 y, especially those <2 ya 
 Residents of a chronic care facility or nursing home 
Underlying condition or treatment with common examplesb 
 Chronic pulmonary disease Asthma 
 Cystic fibrosis 
 Compromised respiratory function (eg, requiring mechanical ventilation, tracheostomy) 
 Cardiovascular disease Hemodynamically significant conditions (excluding hypertension alone) 
 Kidney disease Chronic kidney disease, including end-stage kidney disease 
 Dialysis 
 Hepatic disease Chronic liver disease 
 Cirrhosis11,12  
 Hematologic disease Sickle cell disease 
 Other hemoglobinopathies 
 Metabolic disorders Diabetes mellitus 
 Neurologic and neurodevelopmental conditions Cerebral palsy 
Epilepsy 
 Stroke 
 Intellectual developmental disorder 
 Moderate to severe developmental delay 
 Muscular dystrophy 
 Spinal cord injury 
 Extreme obesity BMI ≥40 for adultsc 
 Immunosuppression Receipt of immuncompromising medications 
 Congenital or acquired immune deficiency, including HIV 
 Asplenia 
Receiving treatment with aspirin or salicylate-containing therapiesd 
Pregnancy and up to 2 wk’ postpartum 

Source: Adapted from Centers for Disease Control and Prevention. Prevention and control of seasonal influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices, United States, 2022–2023 influenza season. MMWR Recomm Rep. 2022; in press.

a

Regardless of the presence of underlying medical conditions.

b

List of examples is not exhaustive.

c

Not well defined in children but could consider BMI ≥99% for age.

d

Applies to children and adolescents aged <19 years who may be at increased risk of Reye syndrome.

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