American Academy of Pediatrics

TABLE 17

Mean HOMA-IR (n = 25)

First Author	Country	Ages (y)	N	Subgroup (eg, M/F)	Healthy	Overweight	Class I	Class II	Class III	P	Notes	Weight definitions	Population Info
Aylanc	Turkey	Mean = 13.5	88		1.43		5.80			<.001
Bindler	USA	11–14	151		2.32		4.61			<.001
Akinci	Turkey	6–17	41		1.01	1.67				.031		HW: 25th–75th
Valerio	Italy	3–16	150	Children	1.4		2.5			.0001
				Adolescents	1.4		4.2			.0001
Valentini	Italy	5–18	84		2.18	3.69				.002			Patients with Down syndrome
Watts	Australia	6–13	148		1.1	1.6	2.0			<.05
Turchiano	USA	14–18	1185		2.0	2.3	3.8			<.05			Youth of urban minoritized groups
Simsek	Turkey	Mean = 10.8	115		1.38		3.11			<.001
Salawi	Canada	6–19	345			4.0			6.8	.03			Patients referred to pediatric weight management program
Puri	USA	10–18	198		2.1	6.4				<.001			Youth of minoritized groups
Rank	Germany	6–19	463	Males			1.5	2.2		<.001
				Females			1.8	2.7		<.001
Perichart-Perera	Mexico	9–12	88		5.90	7.23	9.97			.001
Perez	US (Puerto Rico)	12–18	101		1.8	4.1				<.001
Nascimento	Portugal	5–18	181		1.14		2.90			<.001
Olza	Spain	6–12	446	Males	1.04		2.21			<.001
				Females	1.14		2.58			<.001
Buchan	UK	12–17	387		1.4	1.1				.064
Bocca	The Netherlands	3–5	75			0.79	1.14			<.01
Bindler	US	Mean = 12.5	150		2.32		4.66			<.001
Garces	Spain	6–8	1048	Males	0.69		1.26			<.001
				Females	0.76		1.18			<.001
Cizmecioglu	USA	10–19	310	No	2.3	2.4	2.7			.006
Norris	USA	Mean = 13.5	225	No	1.7	2.6		4.4		<.0001
Serap	Turkey	6–16	284	Males	1.7		3.5			<.001			Pediatric endocrinology patients
				Females	1.6		3.8			<.001
Valery	Australia	5–17	158	No	2.25	3.58				.002	Median		Indigenous youth
Lennerz	Germany	14–24	431				4.23	5.57	7.37	<.001			Weight management program patients + some community
Kim	Korea	12–13	120		2.0	3.2				<.001			School based

First Author	Country	Ages (y)	N	Subgroup (eg, M/F)	Healthy	Overweight	Class I	Class II	Class III	P	Notes	Weight definitions	Population Info
Aylanc	Turkey	Mean = 13.5	88		1.43		5.80			<.001
Bindler	USA	11–14	151		2.32		4.61			<.001
Akinci	Turkey	6–17	41		1.01	1.67				.031		HW: 25th–75th
Valerio	Italy	3–16	150	Children	1.4		2.5			.0001
				Adolescents	1.4		4.2			.0001
Valentini	Italy	5–18	84		2.18	3.69				.002			Patients with Down syndrome
Watts	Australia	6–13	148		1.1	1.6	2.0			<.05
Turchiano	USA	14–18	1185		2.0	2.3	3.8			<.05			Youth of urban minoritized groups
Simsek	Turkey	Mean = 10.8	115		1.38		3.11			<.001
Salawi	Canada	6–19	345			4.0			6.8	.03			Patients referred to pediatric weight management program
Puri	USA	10–18	198		2.1	6.4				<.001			Youth of minoritized groups
Rank	Germany	6–19	463	Males			1.5	2.2		<.001
				Females			1.8	2.7		<.001
Perichart-Perera	Mexico	9–12	88		5.90	7.23	9.97			.001
Perez	US (Puerto Rico)	12–18	101		1.8	4.1				<.001
Nascimento	Portugal	5–18	181		1.14		2.90			<.001
Olza	Spain	6–12	446	Males	1.04		2.21			<.001
				Females	1.14		2.58			<.001
Buchan	UK	12–17	387		1.4	1.1				.064
Bocca	The Netherlands	3–5	75			0.79	1.14			<.01
Bindler	US	Mean = 12.5	150		2.32		4.66			<.001
Garces	Spain	6–8	1048	Males	0.69		1.26			<.001
				Females	0.76		1.18			<.001
Cizmecioglu	USA	10–19	310	No	2.3	2.4	2.7			.006
Norris	USA	Mean = 13.5	225	No	1.7	2.6		4.4		<.0001
Serap	Turkey	6–16	284	Males	1.7		3.5			<.001			Pediatric endocrinology patients
				Females	1.6		3.8			<.001
Valery	Australia	5–17	158	No	2.25	3.58				.002	Median		Indigenous youth
Lennerz	Germany	14–24	431				4.23	5.57	7.37	<.001			Weight management program patients + some community
Kim	Korea	12–13	120		2.0	3.2				<.001			School based

HW, healthy weight.