American Academy of Pediatrics

TABLE 27

Mean ALT (n = 8)

First Author	Country	Ages (y)	N	Units	Subgroup (eg, M/F)	Total	Healthy	Overweight	Class I	Class II	Class III	P	Notes	Weight definitions	Population Info
Bell	Australia	6–13	283	UI/L			15.94	21.15	24.90			<.002
Zabarsky	USA	7–20	2244	U/L				17	24	25	29	<.001	IV = 26
Valentini	Italy	5–18	84	UI/L			27.57	28.74				NS			Patients with Down syndrome
Salawi	Canada	6–19	345	U/L				24.9			31.6	.001
Hadjiyannakis	Canada	5–17	847	IU/L		25.0			21.0	25.5	30.5	NR			Pediatric weight management program patients
Higgins	Canada	5–19	1332	U/L	Males		17	189	23			<.05		OW = 85th–97th %ile, OB > 97th	Community
					Females		16	16	17			NS		OW = 85th–97th %ile, OB > 97th	Community
Kim	Korea	12–13	120	IU/L			11	19				<.001			School based
Seth	US	Mean 13	767	U/L				41	59	61	64	.001			Steatohepatitis clinic patients

First Author	Country	Ages (y)	N	Units	Subgroup (eg, M/F)	Total	Healthy	Overweight	Class I	Class II	Class III	P	Notes	Weight definitions	Population Info
Bell	Australia	6–13	283	UI/L			15.94	21.15	24.90			<.002
Zabarsky	USA	7–20	2244	U/L				17	24	25	29	<.001	IV = 26
Valentini	Italy	5–18	84	UI/L			27.57	28.74				NS			Patients with Down syndrome
Salawi	Canada	6–19	345	U/L				24.9			31.6	.001
Hadjiyannakis	Canada	5–17	847	IU/L		25.0			21.0	25.5	30.5	NR			Pediatric weight management program patients
Higgins	Canada	5–19	1332	U/L	Males		17	189	23			<.05		OW = 85th–97th %ile, OB > 97th	Community
					Females		16	16	17			NS		OW = 85th–97th %ile, OB > 97th	Community
Kim	Korea	12–13	120	IU/L			11	19				<.001			School based
Seth	US	Mean 13	767	U/L				41	59	61	64	.001			Steatohepatitis clinic patients

NR, not reported; NS, not significant; OB, obese; OW, overweight.