American Academy of Pediatrics

TABLE 29

Mean AST (n = 4)

First Author	Country	Ages (y)	N	Units	Subgroup (eg, M/F)	Total	Healthy	Overweight	Class I	Class II	Class III	P	Notes	Weight definitions	Population Info
Valentini	Italy	5–18	84	UI/L	No		35.00	30.12				0.03			Patients with Down syndrome
Higgins	Canada	5–19	1332	U/L	Males		26	24	25			NS		OW = 85th–97th %ile, OB > 97th	Community
					Females		23	23	23			NS		OW = 85th–97th %ile, OB > 97th	Community
Kim	Korea	12–13	120	IU/L			18	20.5				0.004			School based
Seth	USA	Mean 13	767	U/L				29	35	35	37	0.16			Steatohepatitis clinic patients

First Author	Country	Ages (y)	N	Units	Subgroup (eg, M/F)	Total	Healthy	Overweight	Class I	Class II	Class III	P	Notes	Weight definitions	Population Info
Valentini	Italy	5–18	84	UI/L	No		35.00	30.12				0.03			Patients with Down syndrome
Higgins	Canada	5–19	1332	U/L	Males		26	24	25			NS		OW = 85th–97th %ile, OB > 97th	Community
					Females		23	23	23			NS		OW = 85th–97th %ile, OB > 97th	Community
Kim	Korea	12–13	120	IU/L			18	20.5				0.004			School based
Seth	USA	Mean 13	767	U/L				29	35	35	37	0.16			Steatohepatitis clinic patients

NS, not significant; OB, obese; OW, overweight.