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APPENDIX 3

Apnea Testing in Pediatric Brain Death

AuthornAge RangePaco2Comments
Rowland (1984)41  9 children, 16 apnea tests performed 4 months–13 years Range: 60–116 mm Hg after 15 minutes of apnea No spontaneous respiratory effort noted in any patient during testing. Phenobarbital levels of 10,11.6,18,25 mg/dL were measured in 4 patients, 
Outwater & Rockoff (1984)40  10 children 10 months–13 years Mean 59.5 ± 10.2 mm Hg after 5 minutes of apnea No spontaneous respiratory effort noted in any patient during testing or after support was withdrawn 
Riviello (1988)39  19 children 2 months–15 years Mean 63.9 ± 21.5 mm Hg 2 children with Pco2 levels of 24 mm Hg and 38 mm Hg had spontaneous respirations during the apnea test. All other children had no spontaneous respiratory effort noted after support was withdrawn. 
Paret (1995)42  38 children, 61 apnea tests performed 2 months–17 years Mean 68.07 ± 17.66 after 5 minutes 1 child had spontaneous respiratory effort with a Paco2 of 49 mm Hg. This patient was retested 24 hours later and had no respiratory effort. 
  Mean 81.8 ± 20.2 after 10 minutes  
   Mean 86.88 ± 25.6 after 15 minutes  
AuthornAge RangePaco2Comments
Rowland (1984)41  9 children, 16 apnea tests performed 4 months–13 years Range: 60–116 mm Hg after 15 minutes of apnea No spontaneous respiratory effort noted in any patient during testing. Phenobarbital levels of 10,11.6,18,25 mg/dL were measured in 4 patients, 
Outwater & Rockoff (1984)40  10 children 10 months–13 years Mean 59.5 ± 10.2 mm Hg after 5 minutes of apnea No spontaneous respiratory effort noted in any patient during testing or after support was withdrawn 
Riviello (1988)39  19 children 2 months–15 years Mean 63.9 ± 21.5 mm Hg 2 children with Pco2 levels of 24 mm Hg and 38 mm Hg had spontaneous respirations during the apnea test. All other children had no spontaneous respiratory effort noted after support was withdrawn. 
Paret (1995)42  38 children, 61 apnea tests performed 2 months–17 years Mean 68.07 ± 17.66 after 5 minutes 1 child had spontaneous respiratory effort with a Paco2 of 49 mm Hg. This patient was retested 24 hours later and had no respiratory effort. 
  Mean 81.8 ± 20.2 after 10 minutes  
   Mean 86.88 ± 25.6 after 15 minutes  
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