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TABLE 2

Suggested Criteria for Prompting Molecular Testing for PWS

Age at AssessmentFeatures Sufficient to Prompt DNA Testing
Birth to 2 y Significant hypotonia with poor suck and difficulty with weight gain 
2–6 y Congenital hypotonia with history of poor suck; global developmental delay 
6–12 y History of congenital hypotonia with poor suck (hypotonia often persists), global developmental delay, and excessive eating (hyperphagia; obsession with food) with central obesity if uncontrolled 
13 y through adulthood Cognitive impairment, usually mild mental retardation, excessive eating (hyperphagia; obsession with food) with central obesity if uncontrolled, and hypothalamic hypogonadism and/or typical behavior problems (including temper tantrums and obsessive-compulsive features) 
Age at AssessmentFeatures Sufficient to Prompt DNA Testing
Birth to 2 y Significant hypotonia with poor suck and difficulty with weight gain 
2–6 y Congenital hypotonia with history of poor suck; global developmental delay 
6–12 y History of congenital hypotonia with poor suck (hypotonia often persists), global developmental delay, and excessive eating (hyperphagia; obsession with food) with central obesity if uncontrolled 
13 y through adulthood Cognitive impairment, usually mild mental retardation, excessive eating (hyperphagia; obsession with food) with central obesity if uncontrolled, and hypothalamic hypogonadism and/or typical behavior problems (including temper tantrums and obsessive-compulsive features) 

Adapted from Gunay-Aygun M, Schwartz S, Heeger S, O'Riordan MA, Cassidy SB. Pediatrics. 2001;108(5). Available at: www.pediatrics.org/cgi/content/full/108/5/e92.

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