Skip to Main Content
TABLE 1

Regimens Used to Treat Children With TB Infection

RegimenNo.Dose(s), in mg/kg [Maximum Dose]ScheduleOptimal DurationCompletion Defined AsMode of Administration
INH and rifapentine (3HP) 283 INH: 25 mg/kg (children 2–11 y) [900 mg]; 15 mg/kg (children ≥12 y) [900 mg] Weekly 12 wk Receipt of at least 11 doses over a 16-wk period DOPT 
Rifapentine: 300 mg (10–14 kg); 450 mg (14.1–25 kg); 600 mg (25.1–32 kg); 750 mg (32.1–49.9 kg); 900 mg (≥50 kg) [900 mg] 
RIF (4R) 132 10–20 mg/kg [600 mg] Daily 4 mo Receipt of at least 4 mo over a 6-mo period or 52 observed doses if DOPT DOPT, ESAT, SAT 
INH (9H) 178 20–30 mg/kg [900 mg] Twice weekly 9 mo Receipt of 78 doses DOPT 
INH (9H) 74 10–15 mg/kg [300 mg] Daily 9 mo Receipt of at least 6 mo consecutively or 9 mo over a 12-mo period ESAT, SAT 
RegimenNo.Dose(s), in mg/kg [Maximum Dose]ScheduleOptimal DurationCompletion Defined AsMode of Administration
INH and rifapentine (3HP) 283 INH: 25 mg/kg (children 2–11 y) [900 mg]; 15 mg/kg (children ≥12 y) [900 mg] Weekly 12 wk Receipt of at least 11 doses over a 16-wk period DOPT 
Rifapentine: 300 mg (10–14 kg); 450 mg (14.1–25 kg); 600 mg (25.1–32 kg); 750 mg (32.1–49.9 kg); 900 mg (≥50 kg) [900 mg] 
RIF (4R) 132 10–20 mg/kg [600 mg] Daily 4 mo Receipt of at least 4 mo over a 6-mo period or 52 observed doses if DOPT DOPT, ESAT, SAT 
INH (9H) 178 20–30 mg/kg [900 mg] Twice weekly 9 mo Receipt of 78 doses DOPT 
INH (9H) 74 10–15 mg/kg [300 mg] Daily 9 mo Receipt of at least 6 mo consecutively or 9 mo over a 12-mo period ESAT, SAT 

DOPT provided to the child and administration witnessed by a health department representative. The child’s guardian was asked about possible AEs before each dose of medications. ESAT provided to the family by the health department, but the family was responsible for administering the medication to the child on a daily basis; periodically, the family was called for reminders and queried on adherence and on AEs. For SAT, a prescription was given to the family, who had to then acquire the medication from the pharmacy and administer to the child; there was no system for periodic reminder calls. SAT is an option for families who do not want a health department representative visiting the home, or whose schedule may be sufficiently chaotic that arranging scheduled visits is challenging. For these families, we discuss medication cost before making a joint decision about therapy. In Texas, we can only obtain free medication for our TB infection patients if medication is administered under DOPT or ESAT. In SAT, families do have to purchase medications, and RIF is far more costly to purchase than INH.

Close Modal

or Create an Account

Close Modal
Close Modal