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TABLE 2

Spectrum of Iron Status

ParameterID Without AnemiaIDAIron Overload
SFa ↓ ↓↓ ↑ 
Transferrin saturation ↓ ↓ ↑↑ 
TfR1 ↑↑ ↑↑↑ ↓ 
CHr ↓ ↓ Normal 
Hb Normal ↓ Normal 
Mean corpuscular volume Normal ↓ Normal 
ParameterID Without AnemiaIDAIron Overload
SFa ↓ ↓↓ ↑ 
Transferrin saturation ↓ ↓ ↑↑ 
TfR1 ↑↑ ↑↑↑ ↓ 
CHr ↓ ↓ Normal 
Hb Normal ↓ Normal 
Mean corpuscular volume Normal ↓ Normal 
a

Confounded by the presence of inflammation. If SF is normal or increased and the CRP level is normal, then there is no ID. If SF is decreased, then ID is present regardless of the measure of CRP. If SF is normal or increased and the CRP level is increased, then the presence of ID cannot be determined.

Modified from American Academy of Pediatrics, Committee on Nutrition. Iron deficiency. In: Kleinman RE, ed. Pediatric Nutrition Handbook. 5th ed. Elk Grove Village, IL: American Academy of Pediatrics; 2004:304.

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