Factors Implicated in the Pathogenesis of Apnea of Prematurity
| Central Mechanisms . | Peripheral Reflex Pathways . |
|---|---|
| Decreased central chemosensitivity | Decreased carotid body activity |
| Hypoxic ventilatory depression | Increased carotid body activity |
| Upregulated inhibitory neurotransmitters | Laryngeal chemoreflex |
| Delayed central nervous system development | Excessive bradycardic response |
| Central Mechanisms . | Peripheral Reflex Pathways . |
|---|---|
| Decreased central chemosensitivity | Decreased carotid body activity |
| Hypoxic ventilatory depression | Increased carotid body activity |
| Upregulated inhibitory neurotransmitters | Laryngeal chemoreflex |
| Delayed central nervous system development | Excessive bradycardic response |