American Academy of Pediatrics

TABLE 3

Incidence of Opioid-Related Adverse Events According to Age Category, Timing of Use, Days Since Prescription Filled, and Dose Tertile

	Prescription Exposure Period, d	N Cases	Incidence per 100 000 d	IRR^a	95% CI
Age category, y
12–17	9 380 221	310	3.3	2.22	1.67–2.96
6–11	5 303 297	71	1.3	0.94	0.66–1.33
2–5	3 997 444	56	1.4	Reference	—
Timing of use
Current	5 048 647	263	5.2	2.09	1.58–2.76
Recent	13 632 315	174	1.3	Reference	—
Days since prescription filled, d
1–3	3 339 652	229	6.9	3.31	2.41–4.53
4–7	4 203 526	87	2.1	1.51	1.13–2.02
≥8	11 137 784	121	1.1	Reference	—
Dose (mg/kg per d) tertile
High	6 075 031	177	2.9	1.86	1.45–2.39
Intermediate	6 426 759	160	2.5	1.59	1.23–2.04
Low	6 179 172	100	1.6	Reference	—

	Prescription Exposure Period, d	N Cases	Incidence per 100 000 d	IRR^a	95% CI
Age category, y
12–17	9 380 221	310	3.3	2.22	1.67–2.96
6–11	5 303 297	71	1.3	0.94	0.66–1.33
2–5	3 997 444	56	1.4	Reference	—
Timing of use
Current	5 048 647	263	5.2	2.09	1.58–2.76
Recent	13 632 315	174	1.3	Reference	—
Days since prescription filled, d
1–3	3 339 652	229	6.9	3.31	2.41–4.53
4–7	4 203 526	87	2.1	1.51	1.13–2.02
≥8	11 137 784	121	1.1	Reference	—
Dose (mg/kg per d) tertile
High	6 075 031	177	2.9	1.86	1.45–2.39
Intermediate	6 426 759	160	2.5	1.59	1.23–2.04
Low	6 179 172	100	1.6	Reference	—

—, not applicable.

The Poisson regression model for adjusted IRRs includes age (2–5, 6–11, and 12–17 years), sex, current versus recent use, days since the prescription fill (1–3, 4–7, and ≥8), dose tertile by age, and calendar year (1999–2003, 2004–2007, and 2008–2011). Current use was defined as the time between the filling of the prescription and the end of the days of supply. Recent use was defined as the additional 14 days after the end of the days of supply.

View Large

This Feature Is Available To Subscribers Only