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TABLE 3

Incidence of Opioid-Related Adverse Events According to Age Category, Timing of Use, Days Since Prescription Filled, and Dose Tertile

Prescription Exposure Period, dN CasesIncidence per 100 000 dIRRa95% CI
Age category, y      
 12–17 9 380 221 310 3.3 2.22 1.67–2.96 
 6–11 5 303 297 71 1.3 0.94 0.66–1.33 
 2–5 3 997 444 56 1.4 Reference — 
Timing of use      
 Current 5 048 647 263 5.2 2.09 1.58–2.76 
 Recent 13 632 315 174 1.3 Reference — 
Days since prescription filled, d      
 1–3 3 339 652 229 6.9 3.31 2.41–4.53 
 4–7 4 203 526 87 2.1 1.51 1.13–2.02 
 ≥8 11 137 784 121 1.1 Reference — 
Dose (mg/kg per d) tertile      
 High 6 075 031 177 2.9 1.86 1.45–2.39 
 Intermediate 6 426 759 160 2.5 1.59 1.23–2.04 
 Low 6 179 172 100 1.6 Reference — 
Prescription Exposure Period, dN CasesIncidence per 100 000 dIRRa95% CI
Age category, y      
 12–17 9 380 221 310 3.3 2.22 1.67–2.96 
 6–11 5 303 297 71 1.3 0.94 0.66–1.33 
 2–5 3 997 444 56 1.4 Reference — 
Timing of use      
 Current 5 048 647 263 5.2 2.09 1.58–2.76 
 Recent 13 632 315 174 1.3 Reference — 
Days since prescription filled, d      
 1–3 3 339 652 229 6.9 3.31 2.41–4.53 
 4–7 4 203 526 87 2.1 1.51 1.13–2.02 
 ≥8 11 137 784 121 1.1 Reference — 
Dose (mg/kg per d) tertile      
 High 6 075 031 177 2.9 1.86 1.45–2.39 
 Intermediate 6 426 759 160 2.5 1.59 1.23–2.04 
 Low 6 179 172 100 1.6 Reference — 

—, not applicable.

a

The Poisson regression model for adjusted IRRs includes age (2–5, 6–11, and 12–17 years), sex, current versus recent use, days since the prescription fill (1–3, 4–7, and ≥8), dose tertile by age, and calendar year (1999–2003, 2004–2007, and 2008–2011). Current use was defined as the time between the filling of the prescription and the end of the days of supply. Recent use was defined as the additional 14 days after the end of the days of supply.

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