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TABLE 2

Summary of Findings Comparing MI, No MI in Adolescents With Overweight or Obesity

OutcomesFollow-up moParticipants (Studies)Quality of Evidence (GRADE)I2 StatisticReasons for Downgradinga,bEffect Estimatec MD (95% CI)
BMI 3–13 1185 (10 RCTs) ⊕⊕⊕⊝ 31% (P = .16) Imprecision −0.27 (−0.98 to 0.44) 
Moderate 
BMI percentile 4–7 72 (2 RCTs) ⊕⊕⊕⊝ 0% (P = .46) Imprecision −1.07% (−3.63 to 1.48) 
Moderate 
BMI z score 4–13 628 (6 RCTs) ⊕⊕⊕⊝ 47% (P = .09) Imprecision −0.00 (−0.09 to 0.09) 
Moderate 
Waist circumference 4–13 633 (7 RCTs) ⊕⊕⊕⊝ 0% (P = .45) Imprecision 0.56 cm (−1.07 to 2.19) 
Moderate 
Glucose (fasting) 6–13 290 (3 RCTs) ⊕⊕⊕⊝ 17% (P = .30) Imprecision 0.11 mmol/L (0.01 to 0.21) 
Moderate 
Triglycerides (fasting) 7–13 401 (3 RCTs) ⊕⊕⊝⊝ 77% (P = .01) Imprecision, Inconsistency 0.00 mmol/L (−0.31 to 0.31) 
Low 
Total cholesterol (fasting) 6–12 356 (2 RCTs) ⊕⊕⊕⊝ 0% (P = .39) Imprecision 0.01 mmol/L (−0.17 to 0.18) 
Moderate 
Insulin (fasting) 6–13 291 (3 RCTs) ⊕⊕⊕⊝ 18% (P = .30) Imprecision 5.24 pmol/L (−13.63 to 24.10) 
Moderate 
OutcomesFollow-up moParticipants (Studies)Quality of Evidence (GRADE)I2 StatisticReasons for Downgradinga,bEffect Estimatec MD (95% CI)
BMI 3–13 1185 (10 RCTs) ⊕⊕⊕⊝ 31% (P = .16) Imprecision −0.27 (−0.98 to 0.44) 
Moderate 
BMI percentile 4–7 72 (2 RCTs) ⊕⊕⊕⊝ 0% (P = .46) Imprecision −1.07% (−3.63 to 1.48) 
Moderate 
BMI z score 4–13 628 (6 RCTs) ⊕⊕⊕⊝ 47% (P = .09) Imprecision −0.00 (−0.09 to 0.09) 
Moderate 
Waist circumference 4–13 633 (7 RCTs) ⊕⊕⊕⊝ 0% (P = .45) Imprecision 0.56 cm (−1.07 to 2.19) 
Moderate 
Glucose (fasting) 6–13 290 (3 RCTs) ⊕⊕⊕⊝ 17% (P = .30) Imprecision 0.11 mmol/L (0.01 to 0.21) 
Moderate 
Triglycerides (fasting) 7–13 401 (3 RCTs) ⊕⊕⊝⊝ 77% (P = .01) Imprecision, Inconsistency 0.00 mmol/L (−0.31 to 0.31) 
Low 
Total cholesterol (fasting) 6–12 356 (2 RCTs) ⊕⊕⊕⊝ 0% (P = .39) Imprecision 0.01 mmol/L (−0.17 to 0.18) 
Moderate 
Insulin (fasting) 6–13 291 (3 RCTs) ⊕⊕⊕⊝ 18% (P = .30) Imprecision 5.24 pmol/L (−13.63 to 24.10) 
Moderate 
a

High risk of bias due to lack of blinding; less crucial in objective outcome measurements. Potential limitations unlikely lower the confidence in estimate of effect. No serious limitation; do not downgrade.

b

Participant age range included adolescent populations. When mean participant age was <12 y, authors were contacted for direct adolescent specific data. Greater percentage of girls than boys overall. No serious limitation; do not downgrade.

c

Inverse-variance statistical method using a fixed or random (when I2 >50%) effects analysis model with an MD effect measure produced by RevMan.

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