American Academy of Pediatrics

TABLE 2

Study Characteristics in Preterm (<35 Weeks) Retrospective Observational Cohort Studies

Study	Study Characteristics					Total Patients	Gestational Age, wk	Patients by Oxygen Levels, n		Oxygen Level Definition, %	O₂ Sat Target	Preterm Subgroup, wk			Outcome
Study	Years of Recruitment	Country of Recruitment	Multi- or Single Center	Design	Blinded	Total Patients	Gestational Age, wk	Low	High	Oxygen Level Definition, %	O₂ Sat Target	≤28	≤32	<35	STM	LTM	NDI	Other
Dawson et al²⁷	2006–2007	Australia	Single	Prospective before and after	No	125	<30	105	20	Low 21; high 100	90%	—	Yes	Yes	Yes	—	—	—
Rabi et al³³	2004–2009	Canada	Multi	Retrospective cohort	No	2326	<28	1244	1082	Low 21; high 100	Various	Yes	Yes	Yes	Yes	—	—	Yes
Soraisham et al³⁶	2010–2011	Canada	Multi	Retrospective cohort	No	1825	≤28	445	581	Low 21; high 100	Various	Yes	Yes	Yes	Yes	Yes	Yes	Yes
Kapadia et al³⁵	2009–2012	United States	Single	Retrospective before and after	No	161	≤28	89	110	Low 21; high 100	85%–94%	Yes	Yes	Yes	Yes	Yes	Yes	Yes

Study	Study Characteristics					Total Patients	Gestational Age, wk	Patients by Oxygen Levels, n		Oxygen Level Definition, %	O₂ Sat Target	Preterm Subgroup, wk			Outcome
Study	Years of Recruitment	Country of Recruitment	Multi- or Single Center	Design	Blinded	Total Patients	Gestational Age, wk	Low	High	Oxygen Level Definition, %	O₂ Sat Target	≤28	≤32	<35	STM	LTM	NDI	Other
Dawson et al²⁷	2006–2007	Australia	Single	Prospective before and after	No	125	<30	105	20	Low 21; high 100	90%	—	Yes	Yes	Yes	—	—	—
Rabi et al³³	2004–2009	Canada	Multi	Retrospective cohort	No	2326	<28	1244	1082	Low 21; high 100	Various	Yes	Yes	Yes	Yes	—	—	Yes
Soraisham et al³⁶	2010–2011	Canada	Multi	Retrospective cohort	No	1825	≤28	445	581	Low 21; high 100	Various	Yes	Yes	Yes	Yes	Yes	Yes	Yes
Kapadia et al³⁵	2009–2012	United States	Single	Retrospective before and after	No	161	≤28	89	110	Low 21; high 100	85%–94%	Yes	Yes	Yes	Yes	Yes	Yes	Yes

LTM, long-term mortality; N/A, not available; —, not applicable.