Summary of Results for All Preterm Newborns ≤28 Weeks’ Gestation
| Outcome . | Study Design . | No. Studies . | No. Participants . | Effect Estimate, RR (95% CI) . | I2, % . | GRADE Confidence . |
|---|---|---|---|---|---|---|
| STM | RCT | 7 | 467 | 0.92 (0.43 to 1.94) | 45 | Very low |
| Long-term mortality | RCT | 1 | 86 | 2.11 (0.86 to 5.19) | N/A | Very low |
| NDI long-term | RCT | 1 | 69 | 1.08 (0.58 to 2.03) | N/A | Very low |
| ROP | RCT | 6 | 441 | 0.75 (0.43 to 1.33) | 0 | Very low |
| NEC | RCT | 6 | 441 | 1.62 (0.66 to 3.99) | 0 | Very low |
| BPD | RCT | 7 | 467 | 0.90 (0.64 to 1.28) | 31 | Very low |
| Major IVH (grade III or IV) | RCT | 6 | 441 | 0.84 (0.50 to 1.40) | 12 | Very low |
| Outcome . | Study Design . | No. Studies . | No. Participants . | Effect Estimate, RR (95% CI) . | I2, % . | GRADE Confidence . |
|---|---|---|---|---|---|---|
| STM | RCT | 7 | 467 | 0.92 (0.43 to 1.94) | 45 | Very low |
| Long-term mortality | RCT | 1 | 86 | 2.11 (0.86 to 5.19) | N/A | Very low |
| NDI long-term | RCT | 1 | 69 | 1.08 (0.58 to 2.03) | N/A | Very low |
| ROP | RCT | 6 | 441 | 0.75 (0.43 to 1.33) | 0 | Very low |
| NEC | RCT | 6 | 441 | 1.62 (0.66 to 3.99) | 0 | Very low |
| BPD | RCT | 7 | 467 | 0.90 (0.64 to 1.28) | 31 | Very low |
| Major IVH (grade III or IV) | RCT | 6 | 441 | 0.84 (0.50 to 1.40) | 12 | Very low |
N/A, not available.