American Academy of Pediatrics

TABLE 3

Association of CDA With CBCL Scores

	Adjusted Model 2, β (95% CI)	Adjusted Model 3, β (95% CI)^a	Adjusted Model 4, β (95% CI)^b
CBCL syndrome scales
Internalizing composite^c^,^d^,^e^,^f^,^g^,^h	.16 (−0.16 to 0.47)	.15 (−0.17 to 0.47)	.21 (−0.10 to 0.52)
Emotionally reactive^c^,^d^,^e^,^f^,^g	.22 (−0.06 to 0.49)	.21 (−0.07 to 0.49)	.23 (−0.04 to 0.51)
Anxious and/or depressed^d^,^e^,^f^,^g^,^h	.02 (−0.31 to 0.35)	.03 (−0.30 to 0.36)	.06 (−0.27 to 0.38)
Somatic complaints^c^,^d^,^e^,^f	.05 (−0.23 to 0.32)	.03 (−0.25 to 0.30)	.09 (−0.17 to 0.35)
Withdrawn^c^,^d^,^g^,^h	.19 (−0.14 to 0.52)	.18 (−0.15 to 0.51)	.22 (−0.11 to 0.55)
Externalizing composite^c^,^d^,^e^,^f^,^g^,^h	.26 (−0.06 to 0.58)	.26 (−0.06 to 0.58)	.29 (−0.03 to 0.60)
Attention problems^c^,^d^,^e^,^f^,^g	.03 (−0.30 to 0.35)	.03 (−0.30 to 0.35)	.05 (−0.27 to 0.37)
Aggressive behavior^c^,^d^,^e^,^f^,^g^,^h	.30 (−0.02 to 0.63)	.30 (−0.02 to 0.63)	.32 (0.00 to 0.65)*
Sleep problems^c^,^d^,^e^,^f^,^g^,^h	.20 (−0.13 to0.53)	.21 (−0.12 to 0.54)	.24 (−0.09 to 0.56)
DSM-oriented scales
Affective^d^,^f^,^g^,^h^,ⁱ	−.07 (−0.40 to 0.26)	−.07 (−0.39 to 0.26)	−.02 (−0.34 to 0.30)
Anxiety^e^,^f^,^g	.29 (0.02 to 0.56)**	.29 (0.02 to 0.56)**	.31 (0.04 to 0.57)***
Pervasive development^c^,^d^,^g^,^h	.16 (−0.17 to 0.49)	.16 (−0.17 to 0.49)	.19 (−0.14 to 0.52)
Attention-deficit/hyperactivity^c^,^d^,^e^,^f^,^g^,^h^,ⁱ	.24 (−0.08 to 0.57)	.25 (−0.07 to 0.57)	.26 (−0.06 to 0.58)
Oppositional defiant problems^c^,^d^,^g^,^h	.33 (0.00 to 0.65)*	.33 (0.00 to 0.65)*	.35 (0.02 to 0.67)**

	Adjusted Model 2, β (95% CI)	Adjusted Model 3, β (95% CI)^a	Adjusted Model 4, β (95% CI)^b
CBCL syndrome scales
Internalizing composite^c^,^d^,^e^,^f^,^g^,^h	.16 (−0.16 to 0.47)	.15 (−0.17 to 0.47)	.21 (−0.10 to 0.52)
Emotionally reactive^c^,^d^,^e^,^f^,^g	.22 (−0.06 to 0.49)	.21 (−0.07 to 0.49)	.23 (−0.04 to 0.51)
Anxious and/or depressed^d^,^e^,^f^,^g^,^h	.02 (−0.31 to 0.35)	.03 (−0.30 to 0.36)	.06 (−0.27 to 0.38)
Somatic complaints^c^,^d^,^e^,^f	.05 (−0.23 to 0.32)	.03 (−0.25 to 0.30)	.09 (−0.17 to 0.35)
Withdrawn^c^,^d^,^g^,^h	.19 (−0.14 to 0.52)	.18 (−0.15 to 0.51)	.22 (−0.11 to 0.55)
Externalizing composite^c^,^d^,^e^,^f^,^g^,^h	.26 (−0.06 to 0.58)	.26 (−0.06 to 0.58)	.29 (−0.03 to 0.60)
Attention problems^c^,^d^,^e^,^f^,^g	.03 (−0.30 to 0.35)	.03 (−0.30 to 0.35)	.05 (−0.27 to 0.37)
Aggressive behavior^c^,^d^,^e^,^f^,^g^,^h	.30 (−0.02 to 0.63)	.30 (−0.02 to 0.63)	.32 (0.00 to 0.65)*
Sleep problems^c^,^d^,^e^,^f^,^g^,^h	.20 (−0.13 to0.53)	.21 (−0.12 to 0.54)	.24 (−0.09 to 0.56)
DSM-oriented scales
Affective^d^,^f^,^g^,^h^,ⁱ	−.07 (−0.40 to 0.26)	−.07 (−0.39 to 0.26)	−.02 (−0.34 to 0.30)
Anxiety^e^,^f^,^g	.29 (0.02 to 0.56)**	.29 (0.02 to 0.56)**	.31 (0.04 to 0.57)***
Pervasive development^c^,^d^,^g^,^h	.16 (−0.17 to 0.49)	.16 (−0.17 to 0.49)	.19 (−0.14 to 0.52)
Attention-deficit/hyperactivity^c^,^d^,^e^,^f^,^g^,^h^,ⁱ	.24 (−0.08 to 0.57)	.25 (−0.07 to 0.57)	.26 (−0.06 to 0.58)
Oppositional defiant problems^c^,^d^,^g^,^h	.33 (0.00 to 0.65)*	.33 (0.00 to 0.65)*	.35 (0.02 to 0.67)**

Values are regression coefficients (95% CI) from linear regression models that reflect differences in CBCL z scores on the CBCL syndrome scale and DSM-oriented scale according to CDA. Estimates are based on multiple-imputed data.

Adjusted for confounders in model 2 and additionally adjusted for BMI.

Adjusted for confounders in model 2 and additionally adjusted for gastrointestinal complaints.

Adjusted for sex.

Adjusted for HLA antigen type.

Adjusted for ethnicity.

Adjusted for maternal income.

Adjusted for maternal education level.

Adjusted for maternal antibody level.

Adjusted for birth wt.

P = .05;

P = .02;

***

P = .01.

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